Rodrigo R Munhoz,Alejandro Falcón González,Vanessa A Reed et al.
Rodrigo R Munhoz et al.
Different treatment modalities encompassed under the term 'immunotherapy' have led to major breakthroughs in the treatment of melanoma. Immune checkpoint-blocking antibodies targeting CTLA-4 and PD-1 result in significant activity and prolo...
Conceptual approach to early melanoma detection: models, tools, issues and challenges [0.03%]
早期黑色素瘤检测的概念方法：模型、工具、问题和挑战
Shadi Damanpour,James M Grichnik
Shadi Damanpour
Identification and removal of melanoma early in its development remains the most effective treatment. However, identification of early melanoma remains challenging and may result in unnecessary morbidity due to the excess excision of benign...
Lavinia Spain,Eugenie Younger,Emine Hatipoglu et al.
Lavinia Spain et al.
Pembrolizumab is a humanized IgG4 anti-PD-1 antibody that plays a major role in the treatment of advanced melanoma. Through blockade of PD-1, it leads to an increase in effector T-cell activity in the tumor microenvironment. Clinical trial ...
Report of ipilimumab in a heart transplant patient with metastatic melanoma on tacrolimus [0.03%]
伊皮利姆单抗治疗接受他克莫司免疫抑制治疗的心脏移植合并转移性黑色素瘤患者的疗效报告
Rosie Qin,April Ks Salama
Rosie Qin
Ipilimumab is the first immunotherapy shown to increase overall survival in patients with metastatic melanoma. Currently, there are no accepted guidelines for use of ipilimumab in organ transplant patients. There is only one report in the l...
Case Reports
Melanoma management. 2015 Nov;2(4):311-314. DOI:10.2217/mmt.15.27 2015
The end of the beginning: PD-1 inhibition as the new standard of care first-line immunotherapy in metastatic melanoma [0.03%]
新的起点：PD-1抑制剂成为晚期黑色素瘤一线治疗的新标准疗法
Chad C Cherington,Alan H Bryce
Chad C Cherington
Ikenna Okereke
Ikenna Okereke
Kevin B Kim
Kevin B Kim
Analysis of melanoma recurrence following a negative sentinel lymph node biopsy [0.03%]
阴性 Sentinel 淋巴结活检后的黑色素瘤复发分析
Maggie Hodges,Edward Jones,Teresa Jones et al.
Maggie Hodges et al.
Little attention has been paid to the characteristics and outcomes of patients who experience distant, local or regional recurrence of melanoma following a negative sentinel lymph node biopsy. This article aims to review the published liter...
Adam J Cooper,Matteo S Carlino,Richard F Kefford
Adam J Cooper
The potential to harness the power of the immune system and effectively treat patients with metastatic melanoma is finally being realized with the advent of immune checkpoint inhibitors. These new therapies herald a new era in the treatment...
Belinda Lee,Grant A McArthur
Belinda Lee
Research into the cyclin-dependent kinases and their inhibitors is finally coming into the forefront of clinical research in cancer. Targeted therapies such as BRAF inhibitors have led the way in improving treatment outcomes in advanced mel...