NRAS mutant melanoma: an overview for the clinician for melanoma management [0.03%]
临床医生黑色素瘤治疗中的 NRAS 突变型黑色素瘤概述
Russell W Jenkins,Ryan J Sullivan
Russell W Jenkins
Melanoma is the deadliest form of skin cancer and the incidence continues to rise in the United States and worldwide. Activating mutations in RAS oncogenes are found in roughly a third of all human cancers. Mutations in NRAS occur in approx...
Benjamin Y Kong,Matteo S Carlino,Alexander M Menzies
Benjamin Y Kong
BRAF inhibitors were among the first systemic therapies to show clinical benefit in metastatic melanoma. Here, we review the spectrum of BRAF mutations in melanoma, their role in oncogenesis, clinicopathological associations and response to...
Rajasekharan Somasundaram,Meenhard Herlyn,Stephan N Wagner
Rajasekharan Somasundaram
Melanoma patients develop resistance to both chemotherapy and targeted-therapy drugs. Promising preclinical and clinical results with immune checkpoint inhibitors using antibodies directed against cytotoxic T-lymphocyte-associated protein 4...
Low-dose brachytherapy strategies to treat uveal melanoma: is less more? [0.03%]
低剂量近距离照射治疗脉络膜黑色素瘤：疗效更好吗？
Patrick Oellers,Prithvi Mruthyunjaya
Patrick Oellers
The Collaborative Ocular Melanoma Study (COMS) has established equivalency of globe salvaging brachytherapy compared with enucleation in terms of survival for medium-sized choroidal melanoma. The radiation dose protocol followed by the COMS...
Emerging immune therapy of metastatic melanoma in the older patient: does age really matter? [0.03%]
老年黑色素瘤患者正在兴起的免疫治疗：年龄真的重要吗？
Upendra P Hegde,Bijay Mukherji,Jane M Grant-Kels
Upendra P Hegde
What are the therapeutic implications of increased collagen expression in melanoma cells treated with vemurafenib? [0.03%]
vemurafenib治疗黑色素瘤细胞诱导胶原蛋白表达增加的临床意义是什么？
Constance E Brinckerhoff
Constance E Brinckerhoff
Chiara Vardabasso,Emily Bernstein
Chiara Vardabasso
Alexander L Fogel,Kavita Sarin
Alexander L Fogel
New technologies are increasingly impacting the way melanoma is detected and diagnosed. Devices, software and diagnostics abound, ranging from smartphone applications that purport to predict which lesions are likely to be malignant, to geno...
Weimin Guo,Ting Xu,Jonathan J Lee et al.
Weimin Guo et al.
Melanoma, one of the most virulent forms of human malignancy, is the primary cause of mortality from cancers arising from the skin. The prognosis of metastatic melanoma remains dismal despite targeted therapeutic regimens that exploit our g...
The potential complementary role of targeted alpha therapy in the management of metastatic melanoma [0.03%]
靶向α疗法在转移性黑色素瘤治疗中的潜在互补作用
Michael P Brown,Eva Bezak,Barry J Allen
Michael P Brown
Standard treatments for metastatic melanoma have recently extended survival although many patients still succumb. Targeted alpha therapy (TAT) is a new therapeutic approach in which a cancer-targeting vector is labeled with an alpha-emittin...