Rebecca Jane Lee,Noor Ul-Ain-Tariq,Alberto Fusi et al.
Rebecca Jane Lee et al.
The last 4 years have seen dramatic changes in the treatment of advanced melanoma, largely based on advances in targeted therapy and immunotherapy. This article examines the role of chemotherapy in the modern management of melanoma. We exam...
Peter Hersey,Hojabr Kakavand,James Wilmott et al.
Peter Hersey et al.
The introduction of immunotherapy based on the blockade of the PD1/PD-L1 checkpoints has been associated with high response rates and durable remissions of disease in patients with metastatic melanoma, to the extent that it is now considere...
Léon C van Kempen,Margaret Redpath,Caroline Robert et al.
Léon C van Kempen et al.
Cutaneous melanoma is associated with strong prognostic phenotypic features, such as gender, Breslow's thickness and ulceration, although the biological significance of these variables is largely unknown. It is likely that these features ar...
Douglas B Johnson,Ryan J Sullivan
Douglas B Johnson
Melanoma has traditionally been associated with limited treatment options, and as such, biomarkers such as histopathologic staging and serum lactate dehydrogenase focused on prognosis. The development of effective treatment options shifted ...
Induction of endoplasmic reticulum stress as a strategy for melanoma therapy: is there a future? [0.03%]
内质网应激诱导作为黑素瘤治疗策略：会有未来吗？
David S Hill,Penny E Lovat,Nikolas K Haass
David S Hill
Melanoma cells employ several survival strategies, including induction of the unfolded protein response, which mediates resistance to endoplasmic reticulum (ER) stress-induced apoptosis. Activation of oncogenes specifically suppresses ER st...
Ulrike Leiter,Thomas Eigentler,Claus Garbe
Ulrike Leiter
Follow-up examinations in melanoma aim to detect recurrences or secondary melanomas in an early phase of development. Follow-up guidelines that have been developed in many European countries, the USA and Australia show varying recommendatio...
David Whiteman
David Whiteman
The incidence of melanoma continues to rise in most fair-skinned populations. Strategies to curb the toll from melanoma include targeting the patients who are at highest risk with the aim of either preventing the onset of cancer or interven...
The impact of socioeconomic status on melanoma clinical trial participation: an observational cohort study from Australia [0.03%]
澳大利亚一项关于经济状况对黑色素瘤临床试验参与影响的观察性队列研究
Joshua L Lee,Lauren E Haydu,John F Thompson et al.
Joshua L Lee et al.
Aim: This study aims to determine whether socioeconomic status (SES) is associated with participation in melanoma clinical trials. Patients & methods: ...
Robert O Dillman
Robert O Dillman
Douglas B Johnson,Chengwei Peng,Igor Puzanov
Douglas B Johnson