Joao Jesus,Richard E Chandler
Joao Jesus
Estimating functions provide a very general framework for statistical inference, and are particularly useful when one is either unable or unwilling to specify a likelihood function. This paper aims to provide an accessible review of estimat...
Christopher A Penfold,David L Wild
Christopher A Penfold
Inferring the topology of a gene-regulatory network (GRN) from genome-scale time-series measurements of transcriptional change has proved useful for disentangling complex biological processes. To address the challenges associated with this ...
What you see is not what you get: how sampling affects macroscopic features of biological networks [0.03%]
所见非所得——取样方式影响生物网络宏观特性解析
A Annibale,A C C Coolen
A Annibale
We use mathematical methods from the theory of tailored random graphs to study systematically the effects of sampling on topological features of large biological signalling networks. Our aim in doing so is to increase our quantitative under...
Statistical analysis of nonlinear dynamical systems using differential geometric sampling methods [0.03%]
利用微分几何采样法对非线性动力系统进行统计分析
Ben Calderhead,Mark Girolami
Ben Calderhead
Mechanistic models based on systems of nonlinear differential equations can help provide a quantitative understanding of complex physical or biological phenomena. The use of such models to describe nonlinear interactions in molecular biolog...
Bayesian parameter inference for stochastic biochemical network models using particle Markov chain Monte Carlo [0.03%]
基于粒子马尔可夫链蒙特卡罗的生化网络模型中的贝叶斯参数估计方法研究
Andrew Golightly,Darren J Wilkinson
Andrew Golightly
Computational systems biology is concerned with the development of detailed mechanistic models of biological processes. Such models are often stochastic and analytically intractable, containing uncertain parameters that must be estimated fr...
David J T Sumpter,Richard P Mann,Andrea Perna
David J T Sumpter
Collective animal behaviour is the study of how interactions between individuals produce group level patterns, and why these interactions have evolved. This study has proved itself uniquely interdisciplinary, involving physicists, mathemati...
Biomimetic three-dimensional microenvironment for controlling stem cell fate [0.03%]
用于控制干细胞命运的仿生三维微环境
Hu Zhang,Sheng Dai,Jingxiu Bi et al.
Hu Zhang et al.
Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This commitme...
Experimental and numerical determination of cellular traction force on polymeric hydrogels [0.03%]
基于聚电解质水凝胶的细胞牵引力的实验和数值研究
Soon Seng Ng,Chuan Li,Vincent Chan
Soon Seng Ng
Anchorage-dependent cells such as smooth muscle cells (SMCs) rely on the transmission of actomyosin-generated traction forces to adhere and migrate on the extracellular matrix. The cellular traction forces exerted by SMCs on substrate can b...
Small-angle light scattering to detect strain-directed collagen degradation in native tissue [0.03%]
采用小角光散射技术检测天然组织中由应变引起的胶原降解
Michael C Robitaille,Ramin Zareian,Charles A Dimarzio et al.
Michael C Robitaille et al.
It has been demonstrated that there is a mechanochemical relationship between collagen and collagenolytic enzymes such that increased tensile mechanical strain reduces the enzymatic cutting rate. This mechanochemical relationship has the po...
Non-muscle myosin II induces disassembly of actin stress fibres independently of myosin light chain dephosphorylation [0.03%]
非肌球蛋白II诱导应力纤维分解独立于肌球蛋白轻链去磷酸化作用
Tsubasa S Matsui,Roland Kaunas,Makoto Kanzaki et al.
Tsubasa S Matsui et al.
Dynamic remodelling of actin stress fibres (SFs) allows non-muscle cells to adapt to applied forces such as uniaxial cell shortening. However, the mechanism underlying rapid and selective disassembly of SFs oriented in the direction of shor...