Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation [0.03%]
基于模型的神经调控治疗神经系统疾病：重塑大脑节律
Julien Modolo,Alexandre Legros,Alex W Thomas et al.
Julien Modolo et al.
Electric stimulation has been investigated for several decades to treat, with various degrees of success, a broad spectrum of neurological disorders. Historically, the development of these methods has been largely empirical but has led to a...
Atilla Altinok,Didier Gonze,Francis Lévi et al.
Atilla Altinok et al.
WE CONSIDER AN AUTOMATON MODEL THAT PROGRESSES SPONTANEOUSLY THROUGH THE FOUR SUCCESSIVE PHASES OF THE CELL CYCLE: G1, S (DNA replication), G2 and M (mitosis). Each phase is characterized by a mean duration τ and a variability V. As soon a...
A skeleton model for the network of cyclin-dependent kinases driving the mammalian cell cycle [0.03%]
哺乳动物细胞周期中 cyclin-dependent kinase 网络的骨架模型
Claude Gérard,Albert Goldbeter
Claude Gérard
We previously proposed a detailed, 39-variable model for the network of cyclin-dependent kinases (Cdks) that controls progression along the successive phases of the mammalian cell cycle. Here, we propose a skeleton, 5-variable model for the...
What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform [0.03%]
计算系统生物学及基于系统生物学的药物代谢动力学-效应动力学平台
Maciej Swat,Szymon M Kiełbasa,Sebastian Polak et al.
Maciej Swat et al.
The utility of model repositories is discussed in the context of systems biology (SB). It is shown how such repositories, and in particular their live versions, can be used for computational SB: we calculate the robustness of the yeast glyc...
Differential and integral views of genetics in computational systems biology [0.03%]
计算系统生物学中遗传学的微分和积分观点
Denis Noble
Denis Noble
This article uses an integrative systems biological view of the relationship between genotypes and phenotypes to clarify some conceptual problems in biological debates about causality. The differential (gene-centric) view is incomplete in a...
Denis Noble
Denis Noble