A disproportionality analysis for assessing the safety of FLT3 inhibitors using the FDA Adverse Event Reporting System (FAERS) [0.03%]
基于FDA不良事件报告系统评估FLT3抑制剂安全性的不平衡分析
Jie Zhou,Jinping Zhang,Qiaoyun Wang et al.
Jie Zhou et al.
Objectives: This pharmacovigilance analysis was conducted to assess the safety signals of FMS-related tyrosine kinase 3 (FLT3) inhibitors in a real-world setting using the United States Food and Drug Administration Advers...
Adverse event profiles of CDK4/6 inhibitors: data mining and disproportionality analysis of the FDA adverse event reporting system [0.03%]
基于FDA不良事件报告系统的CDK4/6抑制剂类药物的不良事件特征及 disproportionality分析
Jun Shen,Pingli Luo,Jianmei Xu
Jun Shen
Background: Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors are targeted therapies designed to selectively block CDK4/6, crucial regulators of the cell cycle. These inhibitors play a pivotal role in restoring cell cy...
Safety profile of drugs used in non-cystic fibrosis bronchiectasis: a narrative review [0.03%]
非囊性纤维化支气管扩张症用药的安全性：综述型研究
Henil Upadhyay,Stefano Aliberti,Andrew Husband et al.
Henil Upadhyay et al.
Non-cystic fibrosis bronchiectasis is a long-term lung disease characterised by abnormal dilatation of the bronchi, with patients experiencing chronic productive cough and recurrent exacerbations. Currently, there are no licensed drugs for ...
Enhancing pharmacovigilance for robust drug safety monitoring: addressing underreporting and collaborative solutions [0.03%]
加强药品不良反应监测，保障用药安全：如何正视药物警戒中的漏报问题及协同解决方案
Tanguturi Yella Sree Sudha,Bhumika Meena,Sumit Pareek et al.
Tanguturi Yella Sree Sudha et al.
Development and validation of a risk prediction model for linezolid-induced anemia in elderly patients: a retrospective cohort study [0.03%]
利奈唑胺致老年人贫血风险预测模型的建立和验证：回顾性队列研究
Hongling Ma,Zhaotang Gong,Rihan Wu et al.
Hongling Ma et al.
Background: Linezolid-induced anemia (LI-AN) is a severe adverse reaction, but risk factors of the LI-AN for elderly patients have not been established. O...
Assessing potential risk factors for metamizole-induced leukopenia [0.03%]
评估 metamizole 导致白细胞减少的潜在风险因素
Birgit Brüne,Sarah Sonderer,Maria Bösing et al.
Birgit Brüne et al.
Background: Metamizole is a non-opioid analgesic agent that can rarely cause agranulocytosis, a severe form of leukopenia. Objectives: ...
Impact of different doses of esketamine on the incidence of hypotension in propofol-based sedation for colonoscopy: a randomized controlled trial [0.03%]
异丙酚镇静结肠镜检查中不同剂量右美托咪定对艾司氯胺酮致低血压发生率影响的随机对照试验
Mengyue Fu,Bo Sheng,Rui Liu et al.
Mengyue Fu et al.
Background: Hypovolemia is common in colonoscopy due to fasting and bowel preparation, and propofol itself can reduce systemic vascular resistance, resulting in relative hypovolemia. Therefore, hypotension is not a rare e...
Fetal exposure to isotretinoin in Saudi Arabia: a multicenter real-world data analysis from 2015 to 2020 [0.03%]
沙特阿拉伯2015至2020年异维A酸致胎儿暴露的多中心真实世界数据分析
Yasser Albogami,Ohoud Almadani,Sumaya N Almohareb et al.
Yasser Albogami et al.
Background: Despite its high efficacy in treating severe acne, isotretinoin is associated with serious side effects, including teratogenicity. However, the extent of isotretinoin exposure during pregnancy in Saudi Arabia ...
Pirfenidone-induced liver injury, a case report of a rare idiosyncratic reaction [0.03%]
吡非尼酮致药物性肝损伤1例报告
Florent Fortunati,Antoine Froidure,Pamela Baldin et al.
Florent Fortunati et al.
Nearly all medications carry the risk of drug-induced liver injury (DILI). Idiosyncratic reactions are rare and poorly predictable, and the mechanisms are not always well understood. Pirfenidone is an oral antifibrotic drug used to treat id...
Characterizing medication safety incidents in surgical patients: a retrospective cross-sectional analysis of incident reports [0.03%]
一项回顾性横断面分析：手术患者用药安全事件的特征研究
Noah Sagua,Andrew Carson-Stevens,Kathryn Lynette James
Noah Sagua
Background: Medication-related safety incidents (MSIs) are among the most frequent contributors to preventable harm in hospital patients. There is a paucity of research that explores the factors that contribute to MSIs ac...