Real-world large sample evaluation of drug-related blepharoptosis: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database [0.03%]
基于真实世界大样本的药物性睑下垂评价：FDA不良事件数据库中的药物流行病学分析
Kunhong Xiao,Xiaodong Chen,Shinan Wu et al.
Kunhong Xiao et al.
Background: Blepharoptosis is one of the most common eyelid disorders in clinical ophthalmology. Previous evidence on drug-related blepharoptosis limited to case reports. ...
Impact of clinical pharmacist involvement on emergency department physicians' work-time distribution: a comparative analysis [0.03%]
临床药剂师参与对急诊医师工作时间分配的影响：一项比较分析
Renata Vesela Holis,Beate Hennie Garcia,Elin C Lehnbom et al.
Renata Vesela Holis et al.
Background: Emergency departments (EDs) provide urgent care to diverse patients. Medication-related tasks, crucial for safe diagnosis and treatment, often receive inadequate attention. Clinical pharmacists, experts in med...
The effects of Dexmedetomidine on Recovery from Acute KIdney INjury (DRAIN): a single-center retrospective review using the Medical Information Mart for Intensive Care, fourth edition (MIMIC-IV) [0.03%]
右美托咪定对急性肾损伤恢复的影响(DRAIN):使用医学信息 mart for intensive care第四版(MIMIC-IV)进行单中心回顾性审核
James Harvey Jones,Susannah Fleming
James Harvey Jones
Background: Dexmedetomidine may expedite recovery from acute kidney injury (AKI) in critically ill adults. Methods: This study utilizes...
A hybrid simulation model of HIV program interventions: from transmission behavior to macroeconomic impacts [0.03%]
一个关于艾滋病项目的混合模拟模型：从传播行为到宏观经济发展的影响
William Crown,Erin Britton,Moaven Razavi et al.
William Crown et al.
Background: Considerable progress has been made in the estimation of drug safety treatment effects-particularly with observational medical claims and electronic medical record data. The use of the Target Trial framework, ...
Safety profiles of the new target therapies-pemigatinib, futibatinib, and ivosidenib-for the treatment of cholangiocarcinoma: a systematic review [0.03%]
皮米吉替尼、伏立替尼和伊伏西登ib用于治疗胆管癌的新靶向疗法的安全性：系统综述
Giulia Matranga,Anna Carollo,Miriam Alaimo et al.
Giulia Matranga et al.
Background: Cholangiocarcinoma (CCA) is a cancer with a low survival rate. New drugs targeting molecular alterations, oncogenic mutations, and gene fusions are being tested as second-line treatments. ...
Reflections, operational lessons, and practical insights from a pharmacovigilance inspection: a case example of organizational strategies for medical safety readiness [0.03%]
药物警戒检查的反思、实践经验和操作教训——一个组织策略保证医学安全性的案例分析
Tarek A Hammad,Sasan Sabrdaran,Hesham Aboshady et al.
Tarek A Hammad et al.
Background: Pharmacovigilance (PV) inspections are critical regulatory assessments that evaluate the robustness and compliance of a company's drug safety system. Despite their significance, there is limited published guid...
Increased risk of rhabdomyolysis in patients using statins: a population-based case-control study [0.03%]
他汀类药物使用者横纹肌溶解症风险的增加：基于人群的病例对照研究
Ya-Wen Lu,Jong-Yi Wang,Heng-Jun Lin et al.
Ya-Wen Lu et al.
Background: Statins have been demonstrated to decrease cardiovascular events in high-risk patients. Statin-induced myotoxicity is a major contributor to statin intolerance and often the leading cause of statin discontinua...
Artificial intelligence in pharmacovigilance: advancing drug safety monitoring and regulatory integration [0.03%]
人工智能在药物警戒中的应用：推进药品安全监测和监管整合
Ankit Nagar,Joga Gobburu,Aloka Chakravarty
Ankit Nagar
Artificial intelligence (AI) has rapidly evolved from experimental applications in pharmacovigilance (PV) to being considered for routine use. This review critically examines AI's potential to revolutionize drug safety monitoring, focusing ...
Notch pathway inhibition with crenigacestat (LY3039478) in a phase I first-in-human clinical trial for patients with relapsed or refractory non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia [0.03%]
一项针对复发或难治性非霍奇金淋巴瘤和B细胞慢性淋巴细胞白血病患者的I期首次人体临床试验，采用Notch通路抑制剂Crenigacestat（LY3039478）
Jean-Marie Michot,Zsofia Balogh,Jennifer R Brown et al.
Jean-Marie Michot et al.
Background: Deregulated Notch signaling is implicated in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Crenigacestat (LY3039478) prevents cleavage of Notch proteins and may benefit patients with relap...
How prone are Swedish general practitioners to perform medication reconciliation? A theory-based survey study [0.03%]
瑞典全科医生进行用药重整的意愿如何？一项基于理论的调查研究
Sarah Thelin,Sara Modig,Veronica Milos Nymberg
Sarah Thelin
Background: Drug-related problems are common in older individuals. A medication reconciliation has the goal of identifying and maintaining an accurate medication list and can serve to prevent drug-related problems caused ...