Unveiling unexpected adverse events: post-marketing safety surveillance of gilteritinib and midostaurin from the FDA Adverse Event Reporting database [0.03%]
来自FDA不良事件报告数据库的吉列替尼和米哚妥林上市后再评价的安全监测研究：揭露意想不到的不良事件
Tingting Jiang,Yanping Li,Ni Zhang et al.
Tingting Jiang et al.
Background: Gilteritinib and midostaurin are FLT3 inhibitors that have made significant progress in the treatment of acute myeloid leukemia. However, their real-world safety profile in a large sample population is incompl...
Characterization of children's prospective prescription review and exploration of factors influencing the success of interventions [0.03%]
儿童用药依从性现状分析及影响干预效果的因素探索
Qiang Wen,Chuang Yang,Bangjian Deng et al.
Qiang Wen et al.
Background: Medication safety is crucial in clinical care. Although many hospitals have implemented prospective prescription review systems to manage medication use, the impact of these systems on pediatric patients is no...
Age-stratified analysis of adverse event signals for clarithromycin: a disproportionality analysis using the FDA Adverse Event Reporting System [0.03%]
年龄分层的克拉霉素不良事件分析：使用美国食品药品监督管理局不良事件报告系统进行不平衡分析
Haiyan Mai,Zhenpo Zhang,Yankun Liang et al.
Haiyan Mai et al.
Background: Clarithromycin is a widely used antibiotic, but its safety profile, particularly in different age groups, remains inadequately explored. Objec...
Association between number of medications and indicators of potentially inappropriate polypharmacy: a population-based cohort of older adults in Quebec, Canada [0.03%]
加拿大魁北克老年人大样本队列中用药数量与潜在不适当多药治疗的关联性研究
Alexandre Campeau Calfat,Justin P Turner,Marc Simard et al.
Alexandre Campeau Calfat et al.
Background: As the number of medications increases, the appropriateness of polypharmacy may become questionable due to the heightened risk of medication-related harm. ...
Adverse drug events associated with capecitabine: a real-world pharmacovigilance study based on the FAERS database [0.03%]
基于FAERS数据库的卡培他滨药物不良事件的药物流行病学研究
Rongqiang Liu,Yukai Chen,Shi-Nan Wu et al.
Rongqiang Liu et al.
Background: Capecitabine, a prodrug of 5-fluorouracil, is extensively utilized for the treatment of metastatic breast cancer, colorectal cancer, and gastric cancer. Nevertheless, there exist limitations in comprehending a...
Incidence of antibody-drug conjugate-related hepatotoxicity in breast cancer: a systematic review and meta-analysis [0.03%]
抗体偶联药物相关肝毒性的乳腺癌患者发病率：系统回顾和荟萃分析
Ping Yang,Hengheng Zhang,Jinming Li et al.
Ping Yang et al.
Background: Antibody-drug conjugates (ADCs), as a new type of targeted drug, have been widely used in breast cancer patients in recent years. However, while achieving better efficacy, its hepatotoxicity should not be igno...
Physiologically based pharmacokinetic modeling to predict the effect of risperidone on aripiprazole pharmacokinetics in subjects with different CYP2D6 genotypes and individuals with hepatic impairment [0.03%]
生理药动学模型预测利培酮对阿立哌唑药动学影响及其在不同CYP2D6基因型和肝功能不全患者中的作用
Fan Mou,Zhiwei Huang,Yu Cheng et al.
Fan Mou et al.
Background: Aripiprazole and risperidone, widely used atypical antipsychotics, are commonly adjunctively prescribed in clinical practice. When aripiprazole was combined with risperidone, the genotype of drug-metabolizing ...
Alert prescribing of clozapine: a comparison of five drug-drug interaction sources [0.03%]
氯氮平处方预警：五种药物相互作用数据对比研究
Jeroen Govaerts,Annelies Verluyten,Filip Bouckaert et al.
Jeroen Govaerts et al.
Introduction: Clozapine, an antipsychotic used in the treatment of schizophrenia, is known for its serious side effects. In order to promote patient safety, drug-drug interaction (DDI) databases can be consulted by clinic...
Investigating the impact of a pharmacist intervention on inappropriate prescribing practices at hospital admission and discharge in older patients: a secondary outcome analysis from a randomized controlled trial [0.03%]
药师干预对老年患者住院和出院时不适当用药的影响：一项随机对照试验的次要结果分析
Beate Hennie Garcia,Katharina Kaino Omma,Lars Småbrekke et al.
Beate Hennie Garcia et al.
Background: Inappropriate medication prescribing in older patients increases the risk of poorer health outcomes and increased costs. The IMMENSE trial, integrated a clinical pharmacist into the health care team, to improv...
Determining the optimum dose of remifentanil in combination with propofol for total intravenous anaesthesia in hysteroscopy under Narcotrend and SPI monitoring [0.03%]
在 Narcotrend 和 SPI 监测下确定宫腔镜手术全静脉麻醉七氟烷最优剂量的临床研究
Xiaoyu Zhang,Tao Xu,Xiaohu An et al.
Xiaoyu Zhang et al.
Background: Outpatient hysteroscopic surgery requires patients to be anaesthetised and recover quickly, and the drugs used must be safe and effective. Remifentanil is typically co-administered with propofol as total intra...