No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case-control study [0.03%]
母亲维生素E摄入与儿童心血管畸形风险无关：一项基于人群的病例对照研究
Mária Szilasi,Liza Bártfai,Zoltán Bártfai et al.
Mária Szilasi et al.
Objective: In Hungary, vitamin E is frequently used to prevent repeated or threatened abortion. A previous study showed a higher risk of cardiovascular malformations in the children of pregnant women who had a high vitami...
Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources [0.03%]
药物不良反应的全面评估：适宜的研究选择和数据来源的重要性
Yoon K Loke,Su P Golder,Jan P Vandenbroucke
Yoon K Loke
While systematic reviews and meta-analyses are at the top of the evidence hierarchy, most of the methodology has focused on assessing treatment benefit. Hence, we propose a structured framework for the initial steps of searching and identif...
A review of the safety of anticoagulants in older people using the medicines management pathway: weighing the benefits against the risks [0.03%]
老年抗凝药物安全性评估：利用循证药物管理途径平衡风险和效益的系统评价研究
Beata Bajorek
Beata Bajorek
Anticoagulant drugs maintain a high potential for adverse events due to their inherent risk of haemorrhage and/or complex pharmacology. In addition, compromising the safety of these agents is the context in which they are principally used; ...
Christopher Beer,Poh-Kooi Loh,Yan Gee Peng et al.
Christopher Beer et al.
Objective: Polypharmacy and adverse drug reactions are frequent and important among older people. Few clinical trials have evaluated systematic withdrawal of medications among older people. This small, open, study was con...
Ivabradine: a new rate-limiting therapy for coronary artery disease and heart failure [0.03%]
伊伐布雷定：冠状动脉疾病和心力衰竭的新型心率控制药物
Gordon F Rushworth,Philippe Lambrakis,Stephen J Leslie
Gordon F Rushworth
Ivabradine is a new bradycardic agent acting on the I f channels of sinoatrial nodal cells to decrease the rate of diastolic depolarization and thus heart rate. The benefit of ivabradine over other negatively chronotropic agents is its abse...
Management of hyponatraemia in older people: old threats and new opportunities [0.03%]
老年人低钠血症的治疗：旧威胁与新机遇
Roy L Soiza,Hannah S C Talbot
Roy L Soiza
Hyponatraemia is the commonest electrolyte abnormality seen in clinical practice, and is especially prevalent in frail, older people. However, the serious implications of hyponatraemia in this age group are seldom recognized by clinicians. ...
Jean-Claude Roujeau,Sophie Le Pallec
Jean-Claude Roujeau
Sarah J Mitchell,Sarah N Hilmer
Sarah J Mitchell
Drug-induced liver injury (DILI) is an important cause of hospitalisation and of medication deregistration. In old age, susceptibility to DILI is affected by changes in physiology and increased interindividual variability, compounded by an ...
On the integration and standardization of medication error data: taxonomies, terminologies, causes and contributing factors [0.03%]
关于药物错误数据的集成与标准化：分类法、术语、原因及影响因素
Ibrahim Adham Taib,Andrew Stuart McIntosh
Ibrahim Adham Taib
Objective: A reliable database on the causes and contributing factors of medication errors can inform strategies for their prevention. To form a single database from multiple databases requires a process of integration th...
Gordon Mallarkey,Arduino A Mangoni
Gordon Mallarkey