Sujo Anathhanam,Rachel A Powis,Alison L Cracknell et al.
Sujo Anathhanam et al.
Appropriate prescribing for older adults presents unique challenges to the prescriber. An understanding of the scale of the problems and contributing factors is essential when designing interventions to improve patient safety. The altered p...
Incidence of health insurance claims for thyroid neoplasm and pancreatic malignancy in association with exenatide: signal refinement using active safety surveillance [0.03%]
利拉鲁肽和艾塞那肽注射液与甲状腺癌风险关联的信号生成与信号强化研究报告
David D Dore,John D Seeger,K Arnold Chan
David D Dore
Objectives: As part of a regulatory postmarketing commitment, we assessed the risk of claims for thyroid and pancreatic cancer among users of exenatide using an active drug safety surveillance system. ...
Miao Hu,Bernard M Y Cheung,Brian Tomlinson
Miao Hu
Statins are widely used and have been proven to be effective in the prevention of atherosclerotic vascular disease events, primarily by reducing plasma low-density lipoprotein cholesterol concentrations. Although statins are generally well ...
Risks associated with tiotropium in chronic obstructive pulmonary disease: overview of the evidence to date [0.03%]
噻托溴铵治疗慢性阻塞性肺病的风险：迄今为止的证据概述
Yoon K Loke,Sonal Singh
Yoon K Loke
Tiotropium is a long-acting inhaled anticholinergic agent that is widely used in the treatment of chronic obstructive pulmonary disease (COPD). It was initially launched as the tiotropium HandiHaler formulation, but this was followed by a n...
Evidence-based case report: multiple thrombotic episodes associated with lenalidomide and dexamethasone therapy for multiple myeloma [0.03%]
来那度胺和地塞米松治疗多发性骨髓瘤相关反复血栓事件的循证病例报告
Gordon F Rushworth,Stephen J Leslie,Peter Forsyth et al.
Gordon F Rushworth et al.
Lenalidomide in combination with dexamethasone is a treatment for patients with relapsed or refractory myeloma. Although this combination demonstrates a high level of efficacy, it further exacerbates the hypercoaguable state that exists wit...
Outcomes in patients with gram-negative sepsis treated with gentamicin [0.03%]
治疗革兰氏阴性菌感染性休克患者使用庆大霉素的疗效分析
Peter Pillans,Joel Iedema,Peter Donovan et al.
Peter Pillans et al.
Objective: Recent changes to therapeutic drug monitoring (TDM) of gentamicin have been advocated in Australia. It remains uncertain whether these will have an effect on hard clinical endpoints. The aim of this study was t...
Recent advances in the utility and use of the General Practice Research Database as an example of a UK Primary Care Data resource [0.03%]
以英国初级卫生保健数据资源为例的全科医疗研究数据库的应用及其最新进展
Tim Williams,Tjeerd van Staa,Shivani Puri et al.
Tim Williams et al.
Since its inception in the mid-1980s, the General Practice Research Database (GPRD) has undergone many changes but remains the largest validated and most utilised primary care database in the UK. Its use in pharmacoepidemiology stretches ba...
Evan Gedzelman,Kimford J Meador
Evan Gedzelman
Prescribing antiepileptic drugs (AEDs) in pregnancy is a challenge to the clinician. A multitude of questions arise that must be addressed even prior to conception. In women with proven epilepsy, it may be dangerous to stop or even change t...
Carla Kurkjian,Edward S Kim
Carla Kurkjian
With the 1997 filing of an investigational new drug application for the first agent to target angiogenesis, bevacizumab entered into phase I clinical trials and has now become a mainstay in the treatment of several cancers. Bevacizumab has ...
Michael M Beyea,Amit X Garg,Matthew A Weir
Michael M Beyea
Orlistat is an inhibitor of gastric and pancreatic lipase with proven efficacy in the augmentation and maintenance of weight loss. Although its use has been limited by troublesome but benign gastrointestinal side effects, it has more recent...