A review of the safety of anticoagulants in older people using the medicines management pathway: weighing the benefits against the risks [0.03%]
老年抗凝药物安全性评估：利用循证药物管理途径平衡风险和效益的系统评价研究
Beata Bajorek
Beata Bajorek
Anticoagulant drugs maintain a high potential for adverse events due to their inherent risk of haemorrhage and/or complex pharmacology. In addition, compromising the safety of these agents is the context in which they are principally used; ...
Christopher Beer,Poh-Kooi Loh,Yan Gee Peng et al.
Christopher Beer et al.
Objective: Polypharmacy and adverse drug reactions are frequent and important among older people. Few clinical trials have evaluated systematic withdrawal of medications among older people. This small, open, study was con...
Ivabradine: a new rate-limiting therapy for coronary artery disease and heart failure [0.03%]
伊伐布雷定：冠状动脉疾病和心力衰竭的新型心率控制药物
Gordon F Rushworth,Philippe Lambrakis,Stephen J Leslie
Gordon F Rushworth
Ivabradine is a new bradycardic agent acting on the I f channels of sinoatrial nodal cells to decrease the rate of diastolic depolarization and thus heart rate. The benefit of ivabradine over other negatively chronotropic agents is its abse...
Management of hyponatraemia in older people: old threats and new opportunities [0.03%]
老年人低钠血症的治疗：旧威胁与新机遇
Roy L Soiza,Hannah S C Talbot
Roy L Soiza
Hyponatraemia is the commonest electrolyte abnormality seen in clinical practice, and is especially prevalent in frail, older people. However, the serious implications of hyponatraemia in this age group are seldom recognized by clinicians. ...
Jean-Claude Roujeau,Sophie Le Pallec
Jean-Claude Roujeau
Sarah J Mitchell,Sarah N Hilmer
Sarah J Mitchell
Drug-induced liver injury (DILI) is an important cause of hospitalisation and of medication deregistration. In old age, susceptibility to DILI is affected by changes in physiology and increased interindividual variability, compounded by an ...
On the integration and standardization of medication error data: taxonomies, terminologies, causes and contributing factors [0.03%]
关于药物错误数据的集成与标准化：分类法、术语、原因及影响因素
Ibrahim Adham Taib,Andrew Stuart McIntosh
Ibrahim Adham Taib
Objective: A reliable database on the causes and contributing factors of medication errors can inform strategies for their prevention. To form a single database from multiple databases requires a process of integration th...
Gordon Mallarkey,Arduino A Mangoni
Gordon Mallarkey
John D Balian,Janice C Wherry,Rachpal Malhotra et al.
John D Balian et al.
Medical safety-related risk management is a rapidly evolving and increasingly important aspect of drug approval and market longevity. To effectively meet the challenges of this new era, we describe a risk management roadmap that proactively...
Nicholas M Wilson,Lyn M March,Philip N Sambrook et al.
Nicholas M Wilson et al.
Medication safety must be tailored to the distinctive issues in residential aged-care facilities (RACFs). The health and functional characteristics of their residents are different to those of hospital inpatients and community-dwelling olde...