Primary prevention of neural-tube defects and some other congenital abnormalities by folic acid and multivitamins: history, missed opportunity and tasks [0.03%]
叶酸和多种维生素预防神经管畸形及其他先天性异常的病因研究：历史、机遇及任务
Andrew E Czeizel,Zoltán Bártfai,Ferenc Bánhidy
Andrew E Czeizel
The history of intervention trials of periconception folic acid with multivitamin and folic acid supplementation in women has shown a recent breakthrough in the primary prevention of structural birth defects, namely neural-tube defects and ...
Cora McGreevy,David Williams
Cora McGreevy
A number of drug classes are licensed for the treatment of osteoporosis including bisphosphonates, recombinant human parathyroid hormone (PTH), strontium, hormone replacement therapy (HRT), selective oestrogen receptor modulators (SERMS) an...
New generation antiepileptic drugs: what do they offer in terms of improved tolerability and safety? [0.03%]
新一代抗癫痫药物：它们在耐受性和安全性方面有何改进？
Jacqueline A French,Deana M Gazzola
Jacqueline A French
Over the last two decades a total of 11 antiepileptic drugs (AEDs) have been introduced to the US market. Randomized, placebo-controlled trials have yielded information about each drug's efficacy, tolerability, and safety profile; however, ...
Quantifying nonsteroidal anti-inflammatory drug (NSAID) risk: can combining the evidence with the use of a network meta-analysis provide a solution? [0.03%]
定量评估非甾体抗炎药（NSAIDs）的风险：能否利用网络meta分析结合现有证据解决问题？
Richard John Woodman
Richard John Woodman
Immunogenicity and other problems associated with the use of biopharmaceuticals [0.03%]
生物药物使用中的免疫原性及其他问题
Michael G Tovey,Christophe Lallemand
Michael G Tovey
Biopharmaceuticals are used widely for the treatment of cancer, chronic viral hepatitis, inflammatory, and autoimmune diseases. Biopharmaceuticals such as interferons are well tolerated for the most part with the most common adverse events ...
Pharmacy interventions on prescribing in nursing homes: from evidence to practice [0.03%]
从证据到实践：护理院药房对处方的干预措施
Carmel M Hughes,Kate L Lapane
Carmel M Hughes
Prescribing of medicines for older people who live in nursing homes is a very common intervention. Undoubtedly, medicines have contributed to longevity and improved health outcomes in the population, but they are not without their side effe...
Lesley Wise
Lesley Wise
Pharmacoepidemiology is a relatively young scientific discipline that has seen tremendous growth in interest over the past two decades. This is partly due to changes in the approval of new drugs, which often now require proactive studies to...
Systematic review of treatments for Stevens-Johnson syndrome and toxic epidermal necrolysis using the SCORTEN score as a tool for evaluating mortality [0.03%]
以SCORTEN评分作为评价死亡率的工具治疗Stevens-Johnson综合征和中毒性表皮坏死溶解的系统评价
Jean-Claude Roujeau,Sylvie Bastuji-Garin
Jean-Claude Roujeau
Epidermal necrolysis, whether involving limited, that is, Stevens-Johnson syndrome (SJS), or large, that is, toxic epidermal necrolysis (TEN), areas of the skin surface, is associated with high mortality. A specific prognosis score (SCORTEN...
No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case-control study [0.03%]
母亲维生素E摄入与儿童心血管畸形风险无关：一项基于人群的病例对照研究
Mária Szilasi,Liza Bártfai,Zoltán Bártfai et al.
Mária Szilasi et al.
Objective: In Hungary, vitamin E is frequently used to prevent repeated or threatened abortion. A previous study showed a higher risk of cardiovascular malformations in the children of pregnant women who had a high vitami...
Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources [0.03%]
药物不良反应的全面评估：适宜的研究选择和数据来源的重要性
Yoon K Loke,Su P Golder,Jan P Vandenbroucke
Yoon K Loke
While systematic reviews and meta-analyses are at the top of the evidence hierarchy, most of the methodology has focused on assessing treatment benefit. Hence, we propose a structured framework for the initial steps of searching and identif...