Value of preapproval safety data in predicting postapproval hepatic safety and assessing the legitimacy of class warning [0.03%]
基于获批前安全数据预测获批后的肝脏安全性及评估类别警告合理性的价值研究
Yeong-Liang Lin,Ya-Chi Wu,Churn-Shiouh Gau et al.
Yeong-Liang Lin et al.
Objective: The objective of this study was to systematically evaluate whether preapproval safety data for nonhepatotoxic drugs and hepatotoxic drugs can be compared to improve preapproval prediction of postapproval hepati...
Latest drug safety alerts from the 27th International Conference on Pharmacoepidemiology and Therapeutic Risk Management [0.03%]
第27届国际药物流行病学与治疗风险管理大会的最新药品安全警示报告摘要
Gordon Mallarkey,Arduino A Mangoni
Gordon Mallarkey
Can heparins stimulate bone cancer stem cells and interfere with tumorigenesis? [0.03%]
肝素可以刺激骨癌干细胞并干扰肿瘤发生吗？
M Reza Sadaie
M Reza Sadaie
Heparin and heparan sulfate, a variety of negatively charged highly sulfated polysaccharides, can influence the biological functions of human bone morphogenetic proteins (BMPs). Notably, BMPs control numerous essential biological activities...
Aspirin hypersensitivity and desensitization protocols: implications for cardiac patients [0.03%]
阿司匹林敏感与脱敏处理方案：心脏科患者的临床意义
Phil Lambrakis,Gordon F Rushworth,Jane Adamson et al.
Phil Lambrakis et al.
Aspirin or acetylsalicylic acid is an important therapy for many cardiology patients but hypersensitivity to this drug affects around 1% of the population and intolerance may affect up to 20%. While alternative medications to aspirin are av...
Metabolic activation of clopidogrel: in vitro data provide conflicting evidence for the contributions of CYP2C19 and PON1 [0.03%]
关于氯吡格雷代谢活化的体内数据表明血小板糖蛋白IIb/IIIa受体拮抗剂对他克莫司所致排斥反应的作用：一项随机对照试验
Thomas M Polasek,Matthew P Doogue,John O Miners
Thomas M Polasek
The recent report that clopidogrel efficacy may be more dependent on paraoxonase-1 (PON1) than on cytochrome P450 2C19 (CYP2C19) activity raises questions about the roles of these and other enzymes in clopidogrel activation. To provide insi...
Larisa G Tereshchenko,Ronald D Berger
Larisa G Tereshchenko
The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline E14 recommends 'Thorough QT Study' as a standard assessment of drug-induced QT interval prolongation. ...
Lisa Forsberg,Katarina Wide
Lisa Forsberg
Most pregnant women with epilepsy need pharmacological treatment during pregnancy. Children exposed to antiepileptic drugs have an increased risk of being born with major malformations. Some antiepileptic drugs seem to have negative effects...
Advances in bypassing agent therapy for hemophilia patients with inhibitors to close care gaps and improve outcomes [0.03%]
绕过载体治疗甲型血友病抑制物患者的最新进展以弥合护理缺口并改善预后
Amy D Shapiro,Ulla Hedner
Amy D Shapiro
In the past, patients with hemophilia and inhibitors have had less-than-optimal treatment and have experienced more orthopedic complications than patients without inhibitors. Bypassing agents offer the potential to close treatment gaps betw...
Antithrombotic medicines following intracerebral haemorrhage: where's the evidence? [0.03%]
脑出血后的抗血栓药物治疗：证据何在？
Robert Flynn,Alexander Doney
Robert Flynn
The use of antithrombotic medicines in patients who have a history of intracerebral haemorrhage is widely perceived as being contraindicated. However, many patients with intracerebral haemorrhage may suffer from conditions for which antithr...
Current issues on safety of prokinetics in critically ill patients with feed intolerance [0.03%]
重症喂养不耐受患者促动力药安全性问题探究
Nam Q Nguyen,Swee Lin Chen Yi Mei
Nam Q Nguyen
Feed intolerance in the setting of critical illness should be treated promptly given its adverse impact on morbidity and mortality. The technical difficulty of postpyloric feeding tube placement and the morbidities associated with parentera...