Medication errors and associated serious outcomes in COVID-19 antivirals: a real-world study based on FDA Adverse Event Reporting System database [0.03%]
基于FDA不良事件报告系统数据库的COVID-19抗病毒药物用药错误及严重后果的实证研究
Xiaomo Xiong,Zhanghe Chen,Bingfang Yan
Xiaomo Xiong
Background: The Food and Drug Administration (FDA) authorized three COVID-19 antivirals, including remdesivir, nirmatrelvir/ritonavir, and molnupiravir. Although medication errors involving these treatments have been repo...
Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance [0.03%]
免疫后的复杂慢性不良事件：对疫苗药物警戒的系统性批判与改革建议
Tiff-Annie Kenny
Tiff-Annie Kenny
The COVID-19 pandemic has renewed attention to complex chronic health conditions that challenge conventional biomedical paradigms. Syndromes such as postural orthostatic tachycardia syndrome and myalgic encephalomyelitis/chronic fatigue syn...
Data mining results for reduction of adverse drug-drug interaction events in older adults are clinically applicable [0.03%]
数据挖掘结果可减少老年人不良药物相互作用事件
Katherine M Hunold,Yi Shi,Pengyue Zhang et al.
Katherine M Hunold et al.
Background: Polypharmacy increases the risks of drug-drug interactions (DDIs), which increase the risk of adverse drug events (ADEs). Data mining techniques have described high-order (three or four) drug combinations as h...
Orchestrating generative AI in pharmacovigilance: predicting and preempting the unpredictable [0.03%]
药物流行病学中的生成式AI：预测和预防突发事件
Darmendra Ramcharran,Jeffery L Painter,Vijay Kara et al.
Darmendra Ramcharran et al.
The advent of generative artificial intelligence (GenAI) has introduced both remarkable opportunities and significant challenges in the field of pharmacovigilance (PV). This perspective review reflects on emerging trends, practical use cases,...
Transformer-based models for ADR detection: cross-drug validation and benchmarking against large language models [0.03%]
基于变压器模型的ADR检测：跨药物验证和与大型语言模型基准测试
Minjung Kim,Kyoung Eun Kim,Jae-Hee Kwon et al.
Minjung Kim et al.
Background: Adverse drug reactions (ADRs) are harmful side effects of medications. Social media provides real-time, patient-generated data, though its unstructured format presents challenges. Natural language processing a...
Differential risk of adverse drug reactions with baricitinib across age groups: integrating real-world pharmacovigilance and genetic causal inference [0.03%]
巴瑞克替尼在不同年龄段的不良反应差异风险：基于真实世界药物警戒和基因因果推断整合分析
Huiqiong Zeng,Wei Liu,Aidong Li et al.
Huiqiong Zeng et al.
Background: Baricitinib is widely used for immune-mediated diseases, yet real-world safety in underrepresented age groups and the temporal dynamics of adverse drug reactions (ADRs) remain insufficiently characterized. ...
Impact of recently initiated medications on the incidence of urinary tract infections in patients with type 2 diabetes: an observational case-control study [0.03%]
新启动的药物对2型糖尿病患者尿路感染发病率影响的观察性病例对照研究
Joseph Ben Hill,Alexis Simons,Garth Wright et al.
Joseph Ben Hill et al.
Background: Patients with type 2 diabetes (T2DM) are at risk of developing urinary tract infections (UTIs). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a common medication associated with UTIs in these patients...
Evaluating seizures associated with novel antineoplastic agents during breast cancer treatment using the Food and Drug Administration Adverse Event Reporting System and Canada Vigilance Adverse Reaction Online Database [0.03%]
应用美国食品药品管理局不良事件报告系统及加拿大警惕不良反应在线数据库评估乳腺癌治疗期间新型抗肿瘤药物相关性癫痫发作
Yupeng Sha,Quan Yuan,Yao Qian et al.
Yupeng Sha et al.
Background: There is a rising incidence of neurological adverse events (AEs), such as seizures, associated with novel anticancer agents, warranting investigation. Large-scale studies assessing seizure risk across diverse ...
Cardiotoxicity associated with antineoplastic agents: a pharmacovigilance study based on FDA adverse event reporting system [0.03%]
基于美国食品药品监督管理局不良事件报告系统（FAERS）的抗肿瘤药物心毒性信号检测研究
Xiaohan Qiu,Qinxiao Li,Yiyin Rong et al.
Xiaohan Qiu et al.
Background: Cardiovascular adverse events represent critical complications of antineoplastic therapy with profound implications for cancer survivorship and treatment outcomes. Despite the clinical significance, comprehens...
Interdisciplinary pharmaceutical care model engaging patient participation alleviate the anticholinergic burden in community-dwelling older adults: subgroup analysis of a randomized controlled trial [0.03%]
一项随机对照试验中社区居住老年人药学照护模式参与度的亚组分析：参与型药学照护模式可降低老年患者的抗胆碱能负荷
Li-Yu Chen,Ling-Chiao Liao,Chin-Ju Chuang et al.
Li-Yu Chen et al.
Background: Drugs with anticholinergic (AC) effects can cause adverse reactions such as dry mouth, blurred vision, urinary retention, and cognitive impairment, and have been linked to poorer health outcomes, including red...