Marco Mula
Marco Mula
Topiramate is an antiepileptic drug (AED) with multiple mechanisms of action that has been shown to be effective in a number of neuropsychiatric disorders. However, cognitive dysfunction is frequently observed in such patients, often repres...
Diuretic drugs benefit patients with hypertension more with night-time dosing [0.03%]
高血压患者晚上服用利尿剂效果更佳
Basil N Okeahialam,Esther N Ohihoin,Jayne Na Ajuluchukwu
Basil N Okeahialam
Objectives: Night-time chronotherapy in antihypertensive drugs has been shown to produce better blood pressure control and protect from cardiovascular morbidity and mortality. To date, this has been proven for several dru...
Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance [0.03%]
苯环素的静脉和动脉血栓风险：证据及指导建议
Antonio Palumbo,Carmela Palladino
Antonio Palumbo
Oral immunomodulatory drugs (IMiDs), namely thalidomide, lenalidomide and pomalidomide, interfere with several pathways important for disease progression. Today they play a crucial role in the treatment of multiple myeloma patients, and hav...
Drug-induced QT interval prolongation: mechanisms and clinical management [0.03%]
药物所致的QT间期延长：机制与临床处理措施
Senthil Nachimuthu,Manish D Assar,Jeffrey M Schussler
Senthil Nachimuthu
The prolonged QT interval is both widely seen and associated with the potentially deadly rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form, there is a wide array of drugs that have been implicated in...
Treatment-related progressive multifocal leukoencephalopathy: current understanding and future steps [0.03%]
与治疗相关的进行性多灶性白质脑病：当前的认识和未来的研究方向
Fariha Zaheer,Joseph R Berger
Fariha Zaheer
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disorder of the brain caused by a ubiquitous polyomavirus, JC virus. PML is almost always associated with some underlying immunosuppression and acquired immune deficie...
Acetylsalicylic acid for primary prevention of cardiovascular diseases in older patients with diabetes: do the benefits overcome the risks? [0.03%]
阿司匹林与老年糖尿病患者主要心血管事件预防：收益大于风险吗？
Caroline Sirois,Julie Couture,Jean-Pierre Grégoire
Caroline Sirois
Cardiovascular diseases (CVDs) represent a huge health burden for older patients with diabetes. Acetylsalicylic acid (ASA) has long been used as a cardioprotective agent in primary and secondary prevention of CVD. However, there are importa...
Diabetes and cardiovascular disease: focus on glucagon-like peptide-1 based therapies [0.03%]
糖尿病和心血管疾病：以胰高血糖素样肽-1为基础的疗法:focus
Paul Stranges,Ujjaini Khanderia
Paul Stranges
Type 2 diabetes is a well known risk factor for cardiovascular disease (CVD). While glycemic control has consistently been shown to prevent microvascular complications, large randomized trials have not demonstrated the same consistent benef...
High-risk prescribing and monitoring in primary care: how common is it, and how can it be improved? [0.03%]
初级保健中的高风险处方和监测：有多大的问题？如何改进？
Tobias Dreischulte,Bruce Guthrie
Tobias Dreischulte
The safety of medication use in primary care is an area of increasing concern for health systems internationally. Systematic reviews estimate that 3-4% of all unplanned hospital admissions are due to preventable drug-related morbidity, the ...
Sujo Anathhanam,Rachel A Powis,Alison L Cracknell et al.
Sujo Anathhanam et al.
Appropriate prescribing for older adults presents unique challenges to the prescriber. An understanding of the scale of the problems and contributing factors is essential when designing interventions to improve patient safety. The altered p...
Incidence of health insurance claims for thyroid neoplasm and pancreatic malignancy in association with exenatide: signal refinement using active safety surveillance [0.03%]
利拉鲁肽和艾塞那肽注射液与甲状腺癌风险关联的信号生成与信号强化研究报告
David D Dore,John D Seeger,K Arnold Chan
David D Dore
Objectives: As part of a regulatory postmarketing commitment, we assessed the risk of claims for thyroid and pancreatic cancer among users of exenatide using an active drug safety surveillance system. ...