Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review [0.03%]
作为烟草替代品的电子烟的安全评估和风险评估：一项系统综述
Konstantinos E Farsalinos,Riccardo Polosa
Konstantinos E Farsalinos
Electronic cigarettes are a recent development in tobacco harm reduction. They are marketed as less harmful alternatives to smoking. Awareness and use of these devices has grown exponentially in recent years, with millions of people current...
Pharmacogenomic substudies of randomized controlled trials: consideration of safety outcomes [0.03%]
随机对照试验中的药物基因组学亚研究：安全性结果的考虑因素
Michael J Sorich,Andrew Rowland,Michael D Wiese
Michael J Sorich
Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain [0.03%]
普瑞巴林最新安全性证据及其在神经痛管理中的临床意义
Cory Toth
Cory Toth
Used mainly for the management of neuropathic pain, pregabalin is a gabapentinoid or anticonvulsant that was initially developed as an antiepileptic agent. After more than a decade of experience with pregabalin, experience and studies have ...
Safe use of antithrombotics for stroke prevention in atrial fibrillation: consideration of risk assessment tools to support decision-making [0.03%]
房颤患者预防卒中抗栓药物合理应用的个体化风险评估及决策支持工具考量
Yishen Wang,Beata Bajorek
Yishen Wang
Clinical guidelines advocate stroke prevention therapy in atrial fibrillation (AF) patients, specifically anticoagulation. However, the decision to initiate treatment is based on the risk (bleeding) versus benefit (prevention of stroke) of ...
Juan Antonio Vílchez,Pilar Gallego,Gregory Y H Lip
Juan Antonio Vílchez
The recent development of new oral anticoagulants (NOACs) offers the possibility of efficacy, relative safety and convenience compared with warfarin. This could lead to greater patient compliance, with easier management and improved provisi...
Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications [0.03%]
质子泵抑制剂与维生素和矿物质缺乏风险：证据及其临床意义
Joel J Heidelbaugh
Joel J Heidelbaugh
Proton pump inhibitors (PPIs) remain the superior choice worldwide in antisecretory therapy in the evidence-based treatment of upper gastrointestinal disorders including gastroesophageal reflux disease, erosive esophagitis, dyspepsia and pe...
Wendy S Vargas,Jai S Perumal
Wendy S Vargas
Fingolimod is an oral medication approved for the treatment of relapsing multiple sclerosis (MS). It is unique compared with other approved disease-modifying therapies for MS in that it is the first oral agent and it has a novel mechanism o...
Murtala Jibril,Oluwaseun Egunsola
Murtala Jibril
The Truvada(®) (tenofovir/emtricitabine) and nevirapine combination is increasingly being prescribed for prevention of mother-to-child HIV transmission. There is presently no documented evidence of teratogenicity of either tenofovir/emtric...
Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis [0.03%]
与药物诱导的磷脂症模型相关的尿液苯乙酰基甘氨酸水平升高和线粒体毒性增加
Lucette Doessegger,Georg Schmitt,Barbara Lenz et al.
Lucette Doessegger et al.
Background: Phospholipidosis (PLD) is a lysosomal storage disorder induced by a class of cationic amphiphilic drugs. However, drug-induced PLD is reversible. Evidence of PLD from animal studies with some compounds has led...