Quantification of active pharmaceutical ingredient and impurities in sildenafil citrate obtained from the Internet [0.03%]
网络获得的西地那非杂质与有效活性成分定量分析
Michael A Veronin,Mohammad T Nutan,Uday Krishna Reddy Dodla
Michael A Veronin
Background: The accessibility of prescription drugs produced outside of the United States, most notably sildenafil citrate (innovator product, Viagra®), has been made much easier by the Internet. Of greatest concern to c...
Safety of long-acting beta agonists and inhaled corticosteroids in children and adolescents with asthma [0.03%]
长效β受体激动剂和吸入性皮质类固醇在儿童及青少年哮喘患者中的安全性
Ying Xia,Christina M L Kelton,Liang Xue et al.
Ying Xia et al.
The introduction of long-acting beta agonists (LABAs) was considered a major advance in bronchodilator therapy for adult, as well as pediatric, patients with asthma. However, the use of LABAs has raised safety concerns, especially the poten...
The risk of cutaneous adverse reactions among patients with the HLA-A* 31:01 allele who are given carbamazepine, oxcarbazepine or eslicarbazepine: a perspective review [0.03%]
卡马西平、奥卡西平或埃斯卡西平致皮肤不良反应的风险与HLA-A* 31：01等位基因的相关性：述评
Nahoko Kaniwa,Yoshiro Saito
Nahoko Kaniwa
Carbamazepine is a drug that is widely used for the treatment of epilepsy, trigeminal neuralgia and bipolar disorder. This drug is also known to cause cutaneous adverse drug reactions (cADRs) in up to 10% of patients. The recent progress in...
Associations between different measures of anticholinergic drug exposure and Barthel Index in older hospitalized patients [0.03%]
胆碱受体拮抗剂类药物不同暴露量指标与老年住院患者Barthel指数之间的关联性研究
Clare V Bostock,Roy L Soiza,Arduino A Mangoni
Clare V Bostock
Objective: To compare associations between four measures of anticholinergic exposure (anticholinergic risk scale, ARS; anticholinergic drug burden, DBAC; number and use versus no use of anticholinergic drugs), Barthel Ind...
Preparing for safety issues following drug approval: pre-approval risk management considerations [0.03%]
药品上市后的安全问题防范——上市前的风险管理考量
Gretchen S Dieck,Robert G Sharrar
Gretchen S Dieck
Risk management plans and risk minimization plans as well as postapproval commitment studies are based on risks identified pre-approval that need to be further characterized or minimized in the postmarketing environment. Although the implem...
Robert G Sharrar,Gretchen S Dieck
Robert G Sharrar
The safety profile of a medicinal product may change in the postmarketing environment. Safety issues not identified in clinical development may be seen and need to be evaluated. Methods of evaluating spontaneous adverse experience reports a...
Mark J Bolland,Andrew Grey,Ian R Reid
Mark J Bolland
Calcium supplements have been widely used by older men and women. However, in little more than a decade, authoritative recommendations have changed from encouraging the widespread use of calcium supplements to stating that they should not b...
Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports [0.03%]
选择性5-羟色胺再摄取抑制药与尖端扭转型室速：系统分析个案报告得出的新观点和新方向
Christopher Kogut,Ericka Breden Crouse,W Victor R Vieweg et al.
Christopher Kogut et al.
Objective: In the light of the recent United States Food and Drug Administration (FDA) warning to clinicians on using previously approved doses of citalopram because of the purported higher risk of torsade de pointes (TdP...
Safety of antiobesity drugs [0.03%]
抗肥胖药物的安全性
Bernard Man Yung Cheung,Tommy Tsang Cheung,Nithushi Rajitha Samaranayake
Bernard Man Yung Cheung
Obesity is a major health problem worldwide. Although diet and physical activity are crucial in the management of obesity, the long-term success rate is low. Therefore antiobesity drugs are of great interest, especially when lifestyle modif...
Drug-related falls in older patients: implicated drugs, consequences, and possible prevention strategies [0.03%]
老年人药物相关跌倒：涉及药品、后果及可能的预防策略
Marlies R de Jong,Maarten Van der Elst,Klaas A Hartholt
Marlies R de Jong
Falls are the leading cause of injuries among older adults, aged 65 years and older. Furthermore, falls are an increasing public health problem because of ageing populations worldwide due to an increase in the number of older adults, and an...