Challenges and future perspectives of enhanced passive safety surveillance of influenza vaccines in Europe [0.03%]
欧洲流感疫苗增强型被动安全监测的挑战与未来展望
Marina Amaral de Avila Machado,Sonja Gandhi-Banga,Laurence Serradell et al.
Marina Amaral de Avila Machado et al.
Postmarketing surveillance is critical for confirming the safety profile of vaccines following regulatory approval. This article contributes to the ongoing discussion on safety surveillance strategies for seasonal influenza vaccines in Euro...
Evaluating the patterns of use and safety of lenalidomide treatment in myelodysplastic syndromes: a European, observational multi-registry study [0.03%]
来那度胺治疗骨髓增生异常综合征的使用模式和安全性评价：一项欧洲、观察性多注册表研究
Iris Kim,Aidan Makwana,Victoria Ezenma et al.
Iris Kim et al.
Background: Lenalidomide is an immunomodulatory agent thought to inhibit the growth of del(5q) haematopoietic progenitors in myelodysplastic syndromes (MDS) that was approved for use in Europe for certain forms of these c...
Drug-induced intestinal obstruction: insights from the FDA Adverse Event Reporting System [0.03%]
药物性肠梗阻：来自美国食品药品监督管理局不良事件数据库的见解
He Li,Yingjie Li,Lu Liu et al.
He Li et al.
Background: Intestinal obstruction is a severe abdominal condition that can be triggered by various medications; however, the drugs most strongly and frequently linked to this adverse event (AE) remain insufficiently defi...
Prevalence and predictors of prescribing errors in a primary care setting in Ghana [0.03%]
加纳初级卫生保健机构处方错误的流行率及其预测因素
Richard Delali Agbeko Djochie,Jonathan Boakye-Yiadom,Adwoa Oforiwaa Kwakye et al.
Richard Delali Agbeko Djochie et al.
Background: Prescribing errors are a significant cause of preventable harm in healthcare, particularly in low- and middle-income countries where system-level safeguards are often lacking. However, data on their prevalence...
Integration of pre‑existing cardiovascular comorbidity into CDK4/6 inhibitor selection for breast cancer [0.03%]
合并存在的心血管共病情况以选择乳腺癌的CDK4/6抑制剂治疗
Chanhyun Park,Kiyoung Kim,Nora B Abifaraj et al.
Chanhyun Park et al.
Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors differ in cardiovascular (CV) safety. Ribociclib has been associated with a higher risk of CV adverse events compared to palbociclib and abemaciclib. ...
Effect of ciprofol-assisted sedation on tourniquet-related responses in foot and ankle surgery: a randomized clinical trial [0.03%]
异丙酚辅助镇静对足踝手术止血带反应的影响：一项随机临床试验
Yaoyang Ma,Bingqing Zhu,Shudong Wang et al.
Yaoyang Ma et al.
Background: Tourniquet-related responses are a frequent clinical challenge during foot and ankle surgery under peripheral nerve block. Pharmacologic sedation and analgesia represent a common approach. Ciprofol, a novel in...
Machine learning risk prediction models for medication harm in hospitalised adult patients [0.03%]
住院成人患者用药危害的机器学习风险预测模型
Jonathan Yong Jie Lam,Michael Barras,Ian A Scott et al.
Jonathan Yong Jie Lam et al.
Background: Medication harm is a significant healthcare challenge in hospitalised adult patients. Machine learning (ML) approaches offer the potential to improve prediction accuracy for medication harm by capturing comple...
Prevalence of potentially inappropriate medication use and its association with hospitalization among older adults with chronic disease in the Amhara region, Ethiopia: a multicenter prospective cohort study [0.03%]
埃塞俄比亚阿姆哈拉地区老年人慢性病患者不适当用药的流行率及其与住院的关系：一项多中心前瞻性队列研究
Getachew Yitayew Tarekegn,Fisseha Nigussie Dagnew,Samuel Agegnew Wondm et al.
Getachew Yitayew Tarekegn et al.
Background: Potentially inappropriate medications (PIMs) are common among older adults with chronic diseases and are linked to adverse outcomes, including hospitalization. Evidence on PIM prevalence and its clinical impac...
General practitioner-pharmacist collaboration to enhance deprescribing of psychotropics, sedatives, and anticholinergics among older polypharmacy patients in primary care: study protocol of a cluster-randomized controlled trial (PARTNER) [0.03%]
促进初级保健中老年合并用药患者心理治疗、镇静和抗胆碱药物减药的全科医生-药师合作：集群随机对照试验（合作伙伴）研究方案
Annette Haerdtlein,Kerstin Bernartz,Sophie Peter et al.
Annette Haerdtlein et al.
Background: Appropriate deprescribing of psychotropic, sedative, and anticholinergic potentially inappropriate medication (PSA-PIM) in older adults with polypharmacy can reduce the risk of adverse drug reactions, but is i...
Safety and risk management in clinical trials for chronic wounds with tissue regenerative products [0.03%]
慢性难愈合创面再生医学产品临床试验的安全及风险管理规范专家共识
Marina Alexandra Malikova,Connor Michael Roddy,Nolan Patrick Joyce et al.
Marina Alexandra Malikova et al.
Background: In tissue regenerative trials, investigators operate in the intersection of routine clinical care and research. Often, clinical trials are the only option to introduce innovative treatments to disadvantaged po...