Methotrexate use and risk of abnormal alanine aminotransferase elevation in children with rare inflammatory diseases: a self-controlled case series analysis using a pediatric electronic health record database in Japan [0.03%]
日本儿科电子健康记录数据库中罕见炎症性疾病儿童使用甲氨蝶呤与丙氨酸氨基转移酶异常升高的风险：自身病例对照研究
Masayoshi Nakakuni,Azusa Hara,Kosuke Nakano et al.
Masayoshi Nakakuni et al.
Background: Methotrexate (MTX) is commonly prescribed for pediatric inflammatory diseases. However, clinical data on MTX-induced liver injury in children with rare inflammatory diseases currently remain limited. ...
Pharmacokinetic variability of vancomycin in patients undergoing hematopoietic stem cell transplantation: a retrospective cohort study in Peru [0.03%]
秘鲁造血干细胞移植患者万古霉素的药动学变异：一项回顾性队列研究
Wilder Bolaños-Vargas,Cesar Copaja-Corzo,Alfredo Wong-Chang et al.
Wilder Bolaños-Vargas et al.
Background: Vancomycin exhibits high pharmacokinetic variability, particularly in hematopoietic stem cell transplantation (HSCT) patients, where augmented renal clearance (ARC) may compromise therapeutic exposure. This va...
Real-world pharmacovigilance study on neonatal congenital anomalies associated with maternal drug exposure using the FDA Adverse Event Reporting System [0.03%]
基于美国FDA不良事件报告系统的药物警戒研究及其对新生儿出生缺陷的影响
Jingping Zheng,Zhenpo Zhang,Lin Ma et al.
Jingping Zheng et al.
Background: Congenital anomalies represent a significant public health concern, with maternal drug exposure during pregnancy being a potential modifiable risk factor. While certain medications, such as antiepileptics, are...
Impact of social determinants of health on safety of patients in device clinical trials conducted at a safety-net hospital [0.03%]
社会因素对安全网医院开展的医疗器械临床试验患者安全性的影响研究
Anna C Schneider,Katherine N Cilley,Marina A Malikova
Anna C Schneider
Background: Underrepresentation of various populations in clinical trials limits our understanding of efficacy and safety outcomes, as individuals with diverse backgrounds can respond differently to the same interventions...
Knowledge, attitude, and practice regarding pharmacovigilance among hospital pharmacists in China [0.03%]
中国医院药师关于药物警戒的知识、态度和行为调查
Yinchu Cheng,Tingting Qiu,Xiaole Zhang et al.
Yinchu Cheng et al.
Background: Pharmacovigilance is essential for ensuring patient safety, and hospital pharmacists play a key role in this system. However, their knowledge, attitudes, and practices (KAP) remain understudied in China. ...
Real-world large sample evaluation of drug-related blepharoptosis: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database [0.03%]
基于真实世界大样本的药物性睑下垂评价：FDA不良事件数据库中的药物流行病学分析
Kunhong Xiao,Xiaodong Chen,Shinan Wu et al.
Kunhong Xiao et al.
Background: Blepharoptosis is one of the most common eyelid disorders in clinical ophthalmology. Previous evidence on drug-related blepharoptosis limited to case reports. ...
Impact of clinical pharmacist involvement on emergency department physicians' work-time distribution: a comparative analysis [0.03%]
临床药剂师参与对急诊医师工作时间分配的影响：一项比较分析
Renata Vesela Holis,Beate Hennie Garcia,Elin C Lehnbom et al.
Renata Vesela Holis et al.
Background: Emergency departments (EDs) provide urgent care to diverse patients. Medication-related tasks, crucial for safe diagnosis and treatment, often receive inadequate attention. Clinical pharmacists, experts in med...
The effects of Dexmedetomidine on Recovery from Acute KIdney INjury (DRAIN): a single-center retrospective review using the Medical Information Mart for Intensive Care, fourth edition (MIMIC-IV) [0.03%]
右美托咪定对急性肾损伤恢复的影响(DRAIN):使用医学信息 mart for intensive care第四版(MIMIC-IV)进行单中心回顾性审核
James Harvey Jones,Susannah Fleming
James Harvey Jones
Background: Dexmedetomidine may expedite recovery from acute kidney injury (AKI) in critically ill adults. Methods: This study utilizes...
A hybrid simulation model of HIV program interventions: from transmission behavior to macroeconomic impacts [0.03%]
一个关于艾滋病项目的混合模拟模型：从传播行为到宏观经济发展的影响
William Crown,Erin Britton,Moaven Razavi et al.
William Crown et al.
Background: Considerable progress has been made in the estimation of drug safety treatment effects-particularly with observational medical claims and electronic medical record data. The use of the Target Trial framework, ...
Safety profiles of the new target therapies-pemigatinib, futibatinib, and ivosidenib-for the treatment of cholangiocarcinoma: a systematic review [0.03%]
皮米吉替尼、伏立替尼和伊伏西登ib用于治疗胆管癌的新靶向疗法的安全性：系统综述
Giulia Matranga,Anna Carollo,Miriam Alaimo et al.
Giulia Matranga et al.
Background: Cholangiocarcinoma (CCA) is a cancer with a low survival rate. New drugs targeting molecular alterations, oncogenic mutations, and gene fusions are being tested as second-line treatments. ...