Increasing risk of hemorrhage following concurrent use of Salvia miltiorrhiza and oral anticoagulants: a retrospective self-controlled case series study [0.03%]
丹参与口服抗凝剂联用增加出血风险：自我控制病例系列研究
Jian-An Liao,Teng-Chou Chen,Pony Yee Chee Chai et al.
Jian-An Liao et al.
Background: There has been a growing trend of combining traditional Chinese medicine and Western medicine, but the safety of co-prescribing Salvia miltiorrhiza (Danshen) and anticoagulants remains uncertain. ...
Drug- and patient-specific neurological risk profiles of α1-adrenergic blockers: evidence from FAERS and external validation in JADER [0.03%]
基于FAERS和YADER外部数据验证的α1肾上腺素受体阻断剂引起神经系统的风险特征研究
Xin Hai,Lulu Huang
Xin Hai
Background: α1-Adrenergic blockers are widely used in older patients, yet nervous system adverse events associated with these agents are often considered nonspecific and remain insufficiently characterized at the populat...
The administration of proton pump inhibitors with the CDK4/6 inhibitor abemaciclib does not affect the clinical outcome of metastatic breast cancer patients [0.03%]
质子泵抑制剂与CDK4/6抑制剂阿贝西利联合使用不会影响转移性乳腺癌患者的临床结局
Stefania Crucitta,Paola Cinacchi,Irene Bargagna et al.
Stefania Crucitta et al.
Background: CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route...
Incidence, risk factors, and prediction model of piperacillin/tazobactam-associated hypokalemia in neonates [0.03%]
哌拉西林他唑巴坦致新生儿低钾血症的发病情况、危险因素及预测模型
Jun Wan,Shiteng Lin,Wei Zhuang et al.
Jun Wan et al.
Background: Maintaining optimal potassium levels is critical in neonates. Piperacillin/tazobactam (TZP) is associated with hypokalemia in adults, but neonatal data are limited. ...
Rebound hypertension following prolonged oxymetazoline use: a signal-generating case report [0.03%]
长期使用氧化锌导致的反跳性高血压：一起具有信号意义的病例报告
Domenico Merante
Domenico Merante
Topical nasal decongestants containing α-adrenergic agonists such as oxymetazoline are widely available over the counter and are generally perceived as safe when used as directed. Manufacturer instructions typically recommend limited dosin...
Agglomerative clustering-based drugs graded for the risk signals of drug-induced cognitive disorder: a study on the FAERS database [0.03%]
基于聚集型层次聚类的药物所致认知障碍不良反应风险信号分级研究：以FAERS数据库为例
Bo Lv,Junping Han,Yunli Yu et al.
Bo Lv et al.
Background: Drug-induced cognitive disorder (DICD) is a harmful adverse event influenced by individual factors such as age, gender, and weight. These characteristics make regression models with drug selection, such as Las...
Psychedelic exposure in pregnancy: a scoping review to inform perinatal drug safety and clinical counseling [0.03%]
妊娠期接触迷幻药：一项为围产期药物安全和临床咨询提供信息的纲要性综述
Ovie Martin Albert,Alexander Arthur
Ovie Martin Albert
Psychedelic and psychedelic-adjacent substances, including 3,4-methylenedioxymethamphetamine (MDMA) and classic serotonergic hallucinogens, are undergoing renewed therapeutic investigation and remain in non-medical use. Inadvertent exposure...
Monitoring of QTc in subjects hospitalized for 1 year in an acute psychiatric ward treated with clotiapine and other associated antipsychotics: a retrospective study [0.03%]
回顾性研究：急性精神病病房住院一年患者使用氯氮平及其他联用抗精神病药物的心电QT间期监测
Rosaria Di Lorenzo,Andrea Santoro,Jessica Bonisoli et al.
Rosaria Di Lorenzo et al.
Background: Many antipsychotic medications are responsible for prolonging QTc, a risk factor for sudden death, which is one of the main causes of reduced life expectancy in patients with mental health disorders. ...
Treating hearts and minds: adverse cardiovascular effects of psychiatric medications [0.03%]
心血管系统精神药物的不良影响
Asdaq Shabbir Raja,Stephen J Leslie,Elizabeth Buist et al.
Asdaq Shabbir Raja et al.
Cardiovascular disease (CVD) is one of the leading causes of death in patients with severe mental illness (SMI), being ~3.3 times higher than in the general population. The adverse cardiovascular effects of psychiatric medications have shor...
Antimicrobial stewardship and the antibiotic market: why "Reserve" drugs require new economic models [0.03%]
抗菌药物管理与抗生素市场：为什么“储备”类药物需要新的经济学模式
Eleonora Castellana,Alessia Tarozzo,Rita Viglianti et al.
Eleonora Castellana et al.