Evaluation of quantitative signal detection in EudraVigilance for orphan drugs: possible risk of false negatives [0.03%]
欧盟 Vigibase 中的孤儿药定量信号检测评估：可能存在假阴性风险
Marco Sardella,Calin Lungu
Marco Sardella
Different strategies have been studied to allow a better characterization of the safety profile of orphan drugs soon after their approval. At the end of the development phases only few data are available because of the small number of subje...
Deferasirox in thalassemia: a comparative study between an innovator drug and its copy among a sample of Iraqi patients [0.03%]
deferaxys在地中海贫血中的应用：伊拉克患者样本中的原研药物及其仿制品的比较研究
Aqil M Daher,Hayder Al-Momen,Shaymaa Kadhim Jasim
Aqil M Daher
Background: The health care industry is witnessing an increasing trend in the use of generic medicines because of their presumed low cost compared with innovator medicines. The aim of this study was to determine and compa...
Fall-risk increasing drugs and recurrent injurious falls association in older patients after hip fracture: a cohort study protocol [0.03%]
老年髋部骨折患者用药与跌倒再受伤关联的队列研究方案：增加跌倒风险药物与复发性损伤摔倒之间的联系
Andrea Correa-Pérez,Eva Delgado-Silveira,Sagrario Martín-Aragón et al.
Andrea Correa-Pérez et al.
Polypharmacy and fall-risk increasing drugs (FRIDS) have been associated with injurious falls. However, no information is available about the association between FRIDS and injurious falls after hospital discharge due to hip fracture in a ve...
Prescribing issues in older adults living with HIV: thinking beyond drug-drug interactions with antiretroviral drugs [0.03%]
艾滋病合并老年患者处方问题：抗逆转录病毒药物的用药相互作用以外的问题思考
Françoise Livio,Catia Marzolini
Françoise Livio
Ali Ercan Altınöz,Şengül Tosun Altınöz,Başak Güzel Biltekin et al.
Ali Ercan Altınöz et al.
Levetiracetam (LEV) is a newer second-generation antiepileptic drug that is found to be effective in tonic-clonic seizures, partial onset seizures, and myoclonic seizures. Among antiepileptic drugs, LEV is usually known for fewer adverse dr...
Safety evaluation of intravenous immunoglobulin in pediatric patients: a retrospective, 1-year observational study [0.03%]
儿科患者静脉注射人血浆源免疫球蛋白的安全性评价：一项为期一年的回顾性观察研究
Reem Elajez,Asmaa Ezzeldin,Hossamaldein Gaber
Reem Elajez
Background: Intravenous immunoglobulin (IVIG) is a pooled human plasma protein that has shown efficacy in treating a variety of disorders. IVIG is generally well tolerated and has a good safety profile. There are various ...
Evaluation of methenamine for urinary tract infection prevention in older adults: a review of the evidence [0.03%]
甲硝唑预防老年人泌尿道感染的证据回顾
Amy Chwa,Kevin Kavanagh,Sunny Anne Linnebur et al.
Amy Chwa et al.
Urinary tract infections (UTI) commonly occur in older adults and can lead to more severe, life-threatening infections. Physiological factors that change with age are thought to contribute to the increased frequency of UTI recurrence in old...
Comparison of bleeding risks among non-vitamin K antagonist oral anticoagulants using the Korea adverse event reporting system database [0.03%]
基于韩国不良事件监测系统的新型口服抗凝药物出血风险比较研究
Young-Jin Ko,Seonji Kim,Kyounghoon Park et al.
Young-Jin Ko et al.
Background: In order to ensure safer use of non-vitamin K antagonist oral anticoagulants (NOACs), continuously detecting unexpected adverse drug reactions (ADRs) after market approval is necessary. ...
Adverse events associated with home use of mouthrinses: a systematic review [0.03%]
关于家用漱口水不良事件的系统评价
Gianluca M Tartaglia,Santosh Kumar Tadakamadla,Stephen Thaddeus Connelly et al.
Gianluca M Tartaglia et al.
Background: Poor oral hygiene is strongly associated with oral and systemic diseases. Alongside mechanical tooth cleaning, the adjunctive use of mouthrinses has been widely advocated. Although research on the efficacy of ...