Risk of hepatotoxicity with trastuzumab emtansine in breast cancer patients: a systematic review and meta-analysis [0.03%]
曲妥珠单抗-美坦辛治疗乳腺癌患者肝毒性的风险：系统性回顾和 meta 分析
Amani M Cobert,Catherine Helms,Chris Larck et al.
Amani M Cobert et al.
Background: Trastuzumab emtansine (T-DM1) is an anti-HER2 antibody-drug conjugate indicated for the treatment of HER2-positive breast cancer. One of the most severe adverse events reported with T-DM1 is hepatotoxicity. Th...
Practical applications of regulatory requirements for signal detection and communications in pharmacovigilance [0.03%]
药物警戒信号检测与通信的监管要求实践应用
Marina A Malikova
Marina A Malikova
Pharmacovigilance is a field where communication is crucial, and exchange of information is expected to be done in a timely manner. Information from individual case reports is transmitted from pharmaceutical industry and health professional...
Synthetic cannabinoids and potential cardiac arrhythmia risk: an important message for drug users [0.03%]
合成大麻素与潜在的心律失常风险——致吸毒者的重要警示
Jules C Hancox,Nicola J Kalk,Graeme Henderson
Jules C Hancox
Education around medication review and deprescribing: a survey of medical and pharmacy students' perspectives [0.03%]
医学生和药学学生的用药评估及减药教育调查——现状、障碍及未来方向展望
Alan J Poots,Barry Jubraj,Emily Ward et al.
Alan J Poots et al.
Research into the practice of medication review is developing across the world in response to the ever-increasing burden of inappropriate polypharmacy. Education, training and support of undergraduates and novice practitioners to equip them...
Senol Kobak
Senol Kobak
Secukinumab is an IL-17A antagonist that has proven efficacy in the treatment of patients with ankylosing spondylitis (AS) and psoriatic arthritis. Side effects of the drug include infections, skin rashes, and allergic reactions. Raynaud's ...
Severe cutaneous adverse drug reactions manifesting as Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the national pharmacovigilance center in Nigeria: a database review from 2004 to 2017 [0.03%]
尼日利亚全国药物流行病学中心报告的严重药物相关性皮肤不良反应：来自2004年至2017年数据库的斯蒂文斯-约翰逊综合征和中毒性表皮坏死松解症分析结果
Kazeem Adeola Oshikoya,Ibrahim Abayomi Ogunyinka,Comfort Kunak Ogar et al.
Kazeem Adeola Oshikoya et al.
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions (SCARs). There is scant literature on the characteristics and causes of these conditions among the Nig...
Teaching physicians the GPGP method promotes deprescribing in both inpatient and outpatient settings [0.03%]
教授医师GPGP方法可促进住院和门诊患者的减药实践
Aaron Jason Bilek,Yuval Levy,Haneen Kab et al.
Aaron Jason Bilek et al.
Background: In complex older patients, inappropriate medication use and polypharmacy (IMUP) are commonplace and increasing exponentially. Reducing IMUP is a challenge in multiple clinical contexts, including acute admissi...
Thomas M Polasek,Carl M J Kirkpatrick,Amin Rostami-Hodjegan
Thomas M Polasek
Adverse drug reactions (ADRs) have traditionally been managed by trial and error, adjusting drug and dose selection reactively following patient harm. With an improved understanding of ADRs, and the patient characteristics that increase sus...
Andexanet alfa for reversal of factor Xa inhibitor-associated anticoagulation [0.03%]
.Andexanet 阿法用于逆转因子Xa抑制相关的抗凝反应
Elise Carpenter,Divita Singh,Eric Dietrich et al.
Elise Carpenter et al.
Background: Review of clinical data on andexanet alfa for the reversal of factor Xa (FXa) inhibitor associated anticoagulation. Data sources: ...