Anticholinergic burden in older adult inpatients: patterns from admission to discharge and associations with hospital outcomes [0.03%]
抗胆碱能负荷与老年人住院模式及预后之间的关系
Maria Herrero-Zazo,Rachel Berry,Emma Bines et al.
Maria Herrero-Zazo et al.
Background: Anticholinergic medications are associated with adverse outcomes in older adults and should be prescribed cautiously. We describe the Anticholinergic Risk Scale (ARS) scores of older inpatients and association...
Renin-angiotensin-aldosterone system blockers and region-specific variations in COVID-19 outcomes: findings from a systematic review and meta-analysis [0.03%]
血管紧张素系统阻滞剂与COVID-19区域特异性结局差异：一项系统性回顾和荟萃分析的结果
Upinder Kaur,Sankha Shubhra Chakrabarti,Tejas K Patel
Upinder Kaur
Background and aims: Coronavirus disease 2019 (COVID-19) has been observed to cause a high mortality in people with cardiometabolic diseases. Renin-angiotensin-aldosterone system (RAAS) blockers enhance the expression of ...
Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: a case report [0.03%]
芹菜影响肾移植受者他克莫司血药浓度的一例报告
Melek Kurtaran,Neriman Sila Koc,Melek Seren Aksun et al.
Melek Kurtaran et al.
Sirolimus is an immunosuppressive drug used to prevent graft rejection. Therapeutic drug monitoring is required as with other immunosuppressive drugs. Previous studies have shown the interactions between sirolimus and drugs that affect the ...
Immune checkpoint inhibitor-induced aseptic meningitis and encephalitis: a case-series and narrative review [0.03%]
免疫检查点抑制剂诱导的无菌性脑膜炎和脑炎：病例系列及综述
Laure Thouvenin,Timothée Olivier,Giuseppe Banna et al.
Laure Thouvenin et al.
Background: Along with the increasing use of immune checkpoint inhibitors comes a surge in immune-related toxicity. Here, we review the currently available data regarding neurological immune adverse events, and more speci...
Sodium-glucose cotransporter-2 inhibitors and risk for genitourinary infections in older adults with type 2 diabetes [0.03%]
钠葡萄糖共转运蛋白-2抑制剂与2型糖尿病老年人泌尿生殖系感染的风险关系
Navya Varshney,Sarah J Billups,Joseph J Saseen et al.
Navya Varshney et al.
Background and aims: Although landmark clinical trials have demonstrated an increased risk for genitourinary infection (GUI) after initiation of sodium-glucose cotransporter-2 inhibitor (SGLT2i) therapy that led to an FDA...
Aristolochic acid-associated urinary tract cancers: an updated meta-analysis of risk and oncologic outcomes after surgery and systematic review of molecular alterations observed in human studies [0.03%]
Aristotelia酸相关泌尿道癌症：手术后风险和肿瘤结局的更新meta分析及人类研究中观察到的分子改变系统综述
Yu-Chan Kang,Ming-Hong Chen,Chung-Ying Lin et al.
Yu-Chan Kang et al.
Background: The risk of primary aristolochic acid (AA)-associated urothelial carcinoma (AA-UC) has been summarized by a 2013-published meta-analysis. Given that additional evidence has been continuously reported by origin...
Translating evidence into practice during the COVID-19 pandemic: pitfalls and mileages [0.03%]
新冠肺炎疫情下的循证实践：挑战与出路
Arduino A Mangoni,Gian Luca Erre
Arduino A Mangoni
Association of immune-checkpoint inhibitors and the risk of immune-related colitis among elderly patients with advanced melanoma: real-world evidence from the SEER-Medicare database [0.03%]
基于SEER-Medicare数据库老年黑色素瘤患者使用免疫检查点抑制剂与免疫相关性结肠炎风险的关联：真实世界证据
Abdulaali R Almutairi,Marion Slack,Brian L Erstad et al.
Abdulaali R Almutairi et al.
Background: The use of anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA4) therapy (ipilimumab) and anti-programmed cell-death 1 (anti-PD1) agents (nivolumab and pembrolizumab) in advanced melanoma have been associated wit...
Aisling R Caffrey,Eric P Borrelli
Aisling R Caffrey
A "one-size-fits-all" approach has been the standard for drug dosing, in particular for agents with a wide therapeutic index. The scientific principles of drug titration, most commonly used for medications with a narrow therapeutic index, a...
Neurocognitive effects associated with proprotein convertase subtilisin-kexin type 9 inhibitor use: a narrative review [0.03%]
PCSK9抑制剂使用相关的神经认知效应：叙事综述
Wei C Yuet,Didi Ebert,Michael Jann
Wei C Yuet
Neurocognitive adverse events have been observed with the widespread use of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors or "statins," which reduce low-density lipoprotein cholesterol (LDL-C) levels and subsequently cardiovascular ri...