Effect of ciprofol-assisted sedation on tourniquet-related responses in foot and ankle surgery: a randomized clinical trial [0.03%]
异丙酚辅助镇静对足踝手术止血带反应的影响：一项随机临床试验
Yaoyang Ma,Bingqing Zhu,Shudong Wang et al.
Yaoyang Ma et al.
Background: Tourniquet-related responses are a frequent clinical challenge during foot and ankle surgery under peripheral nerve block. Pharmacologic sedation and analgesia represent a common approach. Ciprofol, a novel in...
Machine learning risk prediction models for medication harm in hospitalised adult patients [0.03%]
住院成人患者用药危害的机器学习风险预测模型
Jonathan Yong Jie Lam,Michael Barras,Ian A Scott et al.
Jonathan Yong Jie Lam et al.
Background: Medication harm is a significant healthcare challenge in hospitalised adult patients. Machine learning (ML) approaches offer the potential to improve prediction accuracy for medication harm by capturing comple...
Prevalence of potentially inappropriate medication use and its association with hospitalization among older adults with chronic disease in the Amhara region, Ethiopia: a multicenter prospective cohort study [0.03%]
埃塞俄比亚阿姆哈拉地区老年人慢性病患者不适当用药的流行率及其与住院的关系：一项多中心前瞻性队列研究
Getachew Yitayew Tarekegn,Fisseha Nigussie Dagnew,Samuel Agegnew Wondm et al.
Getachew Yitayew Tarekegn et al.
Background: Potentially inappropriate medications (PIMs) are common among older adults with chronic diseases and are linked to adverse outcomes, including hospitalization. Evidence on PIM prevalence and its clinical impac...
General practitioner-pharmacist collaboration to enhance deprescribing of psychotropics, sedatives, and anticholinergics among older polypharmacy patients in primary care: study protocol of a cluster-randomized controlled trial (PARTNER) [0.03%]
促进初级保健中老年合并用药患者心理治疗、镇静和抗胆碱药物减药的全科医生-药师合作：集群随机对照试验（合作伙伴）研究方案
Annette Haerdtlein,Kerstin Bernartz,Sophie Peter et al.
Annette Haerdtlein et al.
Background: Appropriate deprescribing of psychotropic, sedative, and anticholinergic potentially inappropriate medication (PSA-PIM) in older adults with polypharmacy can reduce the risk of adverse drug reactions, but is i...
Safety and risk management in clinical trials for chronic wounds with tissue regenerative products [0.03%]
慢性难愈合创面再生医学产品临床试验的安全及风险管理规范专家共识
Marina Alexandra Malikova,Connor Michael Roddy,Nolan Patrick Joyce et al.
Marina Alexandra Malikova et al.
Background: In tissue regenerative trials, investigators operate in the intersection of routine clinical care and research. Often, clinical trials are the only option to introduce innovative treatments to disadvantaged po...
Medication errors and associated serious outcomes in COVID-19 antivirals: a real-world study based on FDA Adverse Event Reporting System database [0.03%]
基于FDA不良事件报告系统数据库的COVID-19抗病毒药物用药错误及严重后果的实证研究
Xiaomo Xiong,Zhanghe Chen,Bingfang Yan
Xiaomo Xiong
Background: The Food and Drug Administration (FDA) authorized three COVID-19 antivirals, including remdesivir, nirmatrelvir/ritonavir, and molnupiravir. Although medication errors involving these treatments have been repo...
Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance [0.03%]
免疫后的复杂慢性不良事件：对疫苗药物警戒的系统性批判与改革建议
Tiff-Annie Kenny
Tiff-Annie Kenny
The COVID-19 pandemic has renewed attention to complex chronic health conditions that challenge conventional biomedical paradigms. Syndromes such as postural orthostatic tachycardia syndrome and myalgic encephalomyelitis/chronic fatigue syn...
Data mining results for reduction of adverse drug-drug interaction events in older adults are clinically applicable [0.03%]
数据挖掘结果可减少老年人不良药物相互作用事件
Katherine M Hunold,Yi Shi,Pengyue Zhang et al.
Katherine M Hunold et al.
Background: Polypharmacy increases the risks of drug-drug interactions (DDIs), which increase the risk of adverse drug events (ADEs). Data mining techniques have described high-order (three or four) drug combinations as h...
Orchestrating generative AI in pharmacovigilance: predicting and preempting the unpredictable [0.03%]
药物流行病学中的生成式AI：预测和预防突发事件
Darmendra Ramcharran,Jeffery L Painter,Vijay Kara et al.
Darmendra Ramcharran et al.
The advent of generative artificial intelligence (GenAI) has introduced both remarkable opportunities and significant challenges in the field of pharmacovigilance (PV). This perspective review reflects on emerging trends, practical use cases,...
Transformer-based models for ADR detection: cross-drug validation and benchmarking against large language models [0.03%]
基于变压器模型的ADR检测：跨药物验证和与大型语言模型基准测试
Minjung Kim,Kyoung Eun Kim,Jae-Hee Kwon et al.
Minjung Kim et al.
Background: Adverse drug reactions (ADRs) are harmful side effects of medications. Social media provides real-time, patient-generated data, though its unstructured format presents challenges. Natural language processing a...