Comparison of two regimens of weekly paclitaxel plus gemcitabine in patients with metastatic breast cancer: propensity score-matched analysis of real-world data [0.03%]
每周紫杉醇联合吉西他滨两种方案在转移性乳腺癌患者中的对比：倾向评分匹配的实际数据分 析
Chengcheng Gong,Yizhao Xie,Yannan Zhao et al.
Chengcheng Gong et al.
Purpose: Weekly gemcitabine + paclitaxel (wGT) administration is widely applied in real-world clinical practice. The 28-day and 21-day regimens of wGT are the most widely accepted regimens. We evaluated the efficacy and s...
Safety of triazole antifungals: a pharmacovigilance study from 2004 to 2021 based on FAERS [0.03%]
唑类抗真菌药的安全性：2004年至2021年基于FAERS的药物警戒研究
Shuang Chai,Jing-Lun Zhan,Li-Mei Zhao et al.
Shuang Chai et al.
Background: Triazole antifungals are widely used as broad-spectrum antifungal activity; however, there are many undetected and unreported adverse events (AEs). ...
A survey on self-medication for the prevention or treatment of COVID-19 and distrust in healthcare of veterans in a primary care setting in the United States [0.03%]
关于自我用药防治COVID-19和美国初级医疗机构退伍军人对医疗保健的不信任的调查研究
Eva Amenta,Larissa Grigoryan,Laura Dillon et al.
Eva Amenta et al.
Background: The SARS-CoV-2 (COVID-19) pandemic brought the public overwhelming and conflicting information. Rates of trust in healthcare professionals have been declining among laypersons over the past five decades. In th...
Risk of venous thromboembolism among women receiving ospemifene: a comparative observational study [0.03%]
接受醋酸奥司他滨治疗的女性发生静脉血栓栓塞的风险：一项对比观察研究
Beth L Nordstrom,Bin Cai,Fabio De Gregorio et al.
Beth L Nordstrom et al.
Introduction: The primary aim of this study was to compare the incidence of venous thromboembolism (VTE) among women initiating ospemifene vs other selective estrogen receptor modulator (SERM) therapies for estrogen-defic...
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and cancer risk: an updated meta-analysis of observational studies [0.03%]
血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂与癌症风险：观察性研究的荟萃分析更新结果
Kayeong Shin,Jiwoo Yang,Yeuni Yu et al.
Kayeong Shin et al.
Introduction: Debate on the association between the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) and the risk of developing cancer has been ongoing for decades. This stu...
Therapeutic drug monitoring and safety evaluation of voriconazole in the treatment of pulmonary fungal diseases [0.03%]
伏立康唑治疗肺真菌病的血药浓度监测及安全性评价
Kunlu Shen,Yu Gu,Yu Wang et al.
Kunlu Shen et al.
Aims: The gene polymorphism of voriconazole metabolism-related liver enzyme is notable in East Asia population. It casts a significant influence on the rational use of voriconazole. We conducted this study to investigate ...
Daniela Baracaldo-Santamaría,Maria José Trujillo-Moreno,Andrés M Pérez-Acosta et al.
Daniela Baracaldo-Santamaría et al.
Self-medication (SM) is a global and growing phenomenon. It represents a public health problem due to antibiotic resistance, risk of adverse drug reactions, drug-drug interactions, disease masking, and increased morbidity. There is not a co...
Pharmacovigilance: reporting requirements throughout a product's lifecycle [0.03%]
药品不良反应报告：产品全生命周期的要求
Sylvia Lucas,Jessica Ailani,Timothy R Smith et al.
Sylvia Lucas et al.
Comprehensive methods for evaluating safety are needed to objectively assess the full risk profile of a medication. The confidence of the prescribing provider in the safety and effectiveness of pharmaceuticals is extremely important. Pharma...
Development of a deprescribing manual for frail older people for use in the COFRAIL study and in primary care [0.03%]
脆弱老年人戒药手册的制定——用于COFRAIL研究和初级保健中的实践
Nina-Kristin Mann,Sven Schmiedl,Achim Mortsiefer et al.
Nina-Kristin Mann et al.
Introduction: Many older adults are affected by multimorbidity and subsequent polypharmacy which is associated with adverse outcomes. This is especially relevant for frail older patients. Polypharmacy may be reduced via d...