The 90% effective dose of ciprofol and propofol with S-ketamine for painless abortion: a randomized, double-blind, sequential dose-finding trial [0.03%]
环丙甲酮和异丙酚与S-氯胺酮用于无痛流产的90%有效剂量：随机双盲，序贯剂量探索试验
Qiang Tao,Qiao Shi,Tao Xu et al.
Qiang Tao et al.
Background: Unlike the propofol-opioids combination, a single dose of S-ketamine with propofol achieves the same anesthetic effects while effectively minimizing adverse reactions in painless abortion. Ciprofol, a novel an...
Seizure following in-office lidocaine administration: a case report on local anesthetic systemic toxicity [0.03%]
局麻药全身毒性一例：办公室内利多卡因应用后发生惊厥
Deana Chan,Christopher Wood,Andre Rafizadeh et al.
Deana Chan et al.
Local anesthetics have a broad application for minor and major surgeries, in outpatient and inpatient settings. Drug dosing, frequency, duration of action, and coadministration with other drugs, are some of many factors that must be conside...
A post-marketing disproportionality analysis of the safety of ribociclib based on the FDA Adverse Event Reporting System [0.03%]
基于FDA不良事件报告系统的ribociclib上市后非均衡性安全性分析
Jiayan Xu,Ruo Wang,Kunwei Shen
Jiayan Xu
Background: Although there are reports of adverse events (AEs) of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, the safety of ribociclib alone has not yet been comprehensively evaluated in real-world clinical pract...
Artificial intelligence in drug development: reshaping the therapeutic landscape [0.03%]
药物开发中的人工智能技术：重塑治疗格局
Sarfaraz K Niazi,Zamara Mariam
Sarfaraz K Niazi
Artificial intelligence (AI) is transforming medication research and development, giving clinicians new treatment options. Over the past 30 years, machine learning, deep learning, and neural networks have revolutionized drug design, target ...
Navigating pharmacokinetic and pharmacodynamics challenges of β-lactam antibiotics in patients with low body weight: efficacy, toxicity, and dosage optimization [0.03%]
低体重患者β-内酰胺类抗生素药代动力学和药效学挑战的应对：有效性、毒性及剂量优化
Yu-Ju Tseng,Chih-Hsun Tai,Guan-Yuan Chen et al.
Yu-Ju Tseng et al.
Background: Patients with low body weight (LBW) often exhibit altered pharmacokinetics (PK) in renal clearance and total body water. These changes complicate β-lactam antibiotic dosing, potentially resulting in suboptima...
Impact of dipeptidyl peptidase-4 inhibitors on incidence of colorectal cancer in patients with type 2 diabetes mellitus: a systematic review and meta-analysis [0.03%]
二肽基肽酶-4抑制剂对2型糖尿病患者结直肠癌发生率的影响：系统评价和荟萃分析
Rongrong Fu,Jingqi Chen,Yingying Fang et al.
Rongrong Fu et al.
Background: The association between dipeptidyl peptidase-4 inhibitors (DPP-4i) exposure and the risk of colorectal cancer (CRC) in patients with type 2 diabetes mellitus (T2DM) is unclear. ...
A critical opinion-based review of hospital pharmacy compounding with respect to the risk of leachable substances due to the off-label use of plastic primary packaging [0.03%]
医院药房配制中关于塑料初级包装非适应症使用导致可萃取物质风险的批判性观点综述
William Bello,Julian Pezzatti,Camille Stampfli et al.
William Bello et al.
Hospital pharmacies play a unique role in healthcare by regularly compounding drug products (DPs) in response to hospital demands and practices, for example, drug shortages, to cater to frail and vulnerable patients with infectious, chronic...
Flecainide use in arrhythmic patients who have structural heart disease [0.03%]
结构心脏病心律失常患者的普鲁卡因胺使用情况
Naruepat Sangpornsuk,Voravut Rungpradubvong,Tachawut Tiensantisuk et al.
Naruepat Sangpornsuk et al.
Background: Current guidelines recommend the use of only on a limited basis in patients with normal or minimal structural heart disease. The CAST study, the only randomized controlled trials, showed increased mortality fr...
Carlos Roncero,Milton Merizalde-Torres,Néstor Szerman et al.
Carlos Roncero et al.
In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remittin...
Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report [0.03%]
一线抗结核药物导致的大疱性表皮松解坏死型药疹(Dress)与史蒂文斯-约翰逊综合征重叠综合症一例报告
Cristian Morán-Mariños,Felix Llanos-Tejada,Rebeca Huamani-Llantoy et al.
Cristian Morán-Mariños et al.
The overlap of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson syndrome (SJS) caused by antituberculosis drugs represents an extremely rare event. This situation can manifest between 2 and 8 weeks after the...