Pleiotropic effects of thyroid hormones: learning from hypothyroidism [0.03%]
甲状腺激素的多效性作用：低甲状腺素血症患者的治疗给我们的启示
Martha Franco,Edmundo Chávez,Oscar Pérez-Méndez
Martha Franco
Hypothyroidism induces several metabolic changes that allow understanding some physiopathological mechanisms. Under experimental hypothyroid conditions in rats, heart and kidney are protected against oxidative damage induced by ischemia rep...
Subclassification of the "grey zone" of thyroid cytology; a retrospective descriptive study with clinical, cytological, and histological correlation [0.03%]
甲状腺细胞学"灰色区域"的亚分类：一项临床、细胞及组织病理相关性的回顾性描述性研究
Mariella Bonzanini,Pierluigi Amadori,Luca Morelli et al.
Mariella Bonzanini et al.
Undetermined thyroid cytology precludes any definitive distinction between malignant and benign lesions. Recently several classifications have been proposed to split this category into two or more cytological subcategories related to differ...
Emina Kasumagic-Halilovic,Asja Prohic,Begler Begovic et al.
Emina Kasumagic-Halilovic et al.
Background. Vitiligo is a common skin disorder characterized by macular depigmentation of the skin. The etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine disfunction may be involved. Obj...
Francesca Marini,Ettore Luzi,Maria Luisa Brandi
Francesca Marini
MicroRNAs (miRNAs) are endogenous noncoding RNAs that negatively regulate gene expression by binding the 3' noncoding region of the messenger RNA targets inducing their cleavage or blocking the protein translation. They play important roles...
Anjali Amin,Waljit S Dhillo,Kevin G Murphy
Anjali Amin
Obesity is a major public health issue worldwide. Current pharmacological treatments are largely unsuccessful. Determining the complex pathways that regulate food intake may aid the development of new treatments. The hypothalamic-pituitary-...
Ameliorative effect of vitamin C on alterations in thyroid hormones concentrations induced by subchronic coadministration of chlorpyrifos and lead in wistar rats [0.03%]
维生素C对氯毗呋柳和铅联合暴露所致大鼠甲状腺激素浓度变化的改善作用
Suleiman F Ambali,Chinedu Orieji,Woziri O Abubakar et al.
Suleiman F Ambali et al.
The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 anima...
Ana Paula Santin,Tania Weber Furlanetto
Ana Paula Santin
Thyroid diseases are more prevalent in women, particularly between puberty and menopause. It is wellknown that estrogen (E) has indirect effects on the thyroid economy. Direct effects of this steroid hormone on thyroid cells have been descr...
Thyroid antibodies and miscarriage: where are we at a generation later? [0.03%]
甲状腺抗体与流产：一代人之后我们处于什么位置？
Alex Stagnaro-Green
Alex Stagnaro-Green
In 1990, an association between thyroid antibody positivity and spontaneous miscarriage was first reported. A generation has passed since the initial observation. Over that time a robust literature has developed which has confirmed the init...
Medullary thyroid carcinoma: molecular signaling pathways and emerging therapies [0.03%]
髓样甲状腺癌：分子信号转导通路及新兴疗法
Karen Gómez,Jeena Varghese,Camilo Jiménez
Karen Gómez
Research on medullary thyroid carcinoma (MTC) over the last 55 years has led to a good understanding of the genetic defects and altered molecular pathways associated with its development. Currently, with the use of genetic testing, patients...
Shioko Kimura
Shioko Kimura
Homeodomain, forkhead domain, and paired domain-containing transcription factors play a major role in development, tissue-specific gene expression, and tissue homeostasis in organs where they are expressed. Recently, their roles in stem cel...