Systematic evaluation of PASEF acquisition strategies in complex metaproteomes [0.03%]
复杂元蛋白质组中PASEF采集策略的系统评估
Feng Xian,Goran Mitulovic,Ranjith Kumar Ravi Kumar et al.
Feng Xian et al.
Metaproteomics measures functional expression in complex microbial communities, but extreme sample complexity and dynamic range challenge acquisition strategies. Trapped ion mobility spectrometry with parallel accumulation-serial fragmentat...
Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12 [0.03%]
多西环素核糖开关G12高效调控功能的机制研究
J Hoetzel,A Walbrun,M Schäfer et al.
J Hoetzel et al.
Synthetic riboswitches provide protein-independent, modular control of gene expression, yet selecting aptamers that reliably couple ligand binding to regulatory switching remains challenging. Here, we identify and mechanistically characteri...
Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels [0.03%]
原子精度的π驱动肽水凝胶纳米纤维及其有序水分通道
Ayaka Ueda,George Broutzakis,Alexander Neuhaus et al.
Ayaka Ueda et al.
Aromatic interactions organize molecules into ordered supramolecular architectures, while peptides form functional soft materials through hydrogen bonding and water-mediated assembly. In peptide-based systems, strong aromatic stacking is ty...
Echelle S Burns,Sara Orofino,Kaiwen Wang et al.
Echelle S Burns et al.
Global shark mortality continues to rise despite increasing regulations aimed at limiting shark fishing and trade. Regulatory measures may influence shark product markets, but this relationship has been difficult to quantify because of frag...
A game-theoretic attack-defense framework for the study of network resilience [0.03%]
用于研究网络弹性的攻防博弈框架
Kaiwen Zhao,Jianxi Gao,Qi Su
Kaiwen Zhao
The rapid evolution of communication technologies and the Internet of Things has enhanced system interconnectivity, allowing localized disruptions to cascade into failures. Many such breakdowns are not purely accidental but emerge from inte...
Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study [0.03%]
特发性肺纤维化吸入LTI-03的剂量递增研究
Philip L Molyneaux,Nikhil A Hirani,Collin C K Chia et al.
Philip L Molyneaux et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited treatment options. LTI-03 promotes alveolar epithelial cell survival and reduces profibrotic protein expression in experimental models of IPF. In this Pha...
Clinical Trial
Nature communications. 2026 Jul 31;17(1):7620. DOI:10.1038/s41467-026-75291-3 2026
Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization [0.03%]
EHD2纤丝在弯曲膜上的结构为笼状囊泡颈部稳定提供了一种模型
Elena Vázquez-Sarandeses,Vasilii Mikirtumov,Jeffrey K Noel et al.
Elena Vázquez-Sarandeses et al.
Caveolae are flask-shaped invaginations of the plasma membrane serving critical functions in mechano-protection and signal transduction. Caveolar dynamics, such as caveolar movement within the plasma membrane or endocytosis, relies on preci...
Decadal sink-source shifts of forest aboveground carbon since 1988 [0.03%]
1988年以来森林地上生物量碳由 sink 转变为 source 的年代际变化
Zhen Qian,Sebastian Bathiany,Teng Liu et al.
Zhen Qian et al.
Forest ecosystems are vital to the global carbon cycle, yet their long-term aboveground carbon (AGC) dynamics remain uncertain. Here, we integrate multi-source satellite observations with probabilistic deep learning models to reconstruct a ...
Spatiotemporal patterns of lower-band whistler mode waves in the magnetosphere of Earth [0.03%]
地球磁层中低频偶极子波的时空分布规律研究
O Santolík,I Kolmašová,U Taubenschuss et al.
O Santolík et al.
Electromagnetic emissions of lower-band chorus and exohiss waves are known to interact with electrons in the Earth's outer radiation belt. Understanding statistical properties of these natural emissions is essential for modeling space weath...
Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial [0.03%]
洛索洛芬和泼尼松龙治疗新冠后遗症和心脏炎症的随机双盲安慰剂对照试验
Valentina O Puntmann,Eike Nagel,Dietrich Beitzke et al.
Valentina O Puntmann et al.
Persistent cardiac symptoms are common in post-COVID syndrome, even without structural heart disease. Evidence implicates immune dysregulation, endothelial dysfunction and low-grade cardiovascular inflammation. Yet no targeted treatment exi...
Randomized Controlled Trial
Nature communications. 2026 Jul 30;17(1):7599. DOI:10.1038/s41467-026-75991-w 2026