The 2nd DBCLS BioHackathon: interoperable bioinformatics Web services for integrated applications [0.03%]
第二届DBCLS 生物研讨会：综合应用的互操作生物信息学网络服务
Toshiaki Katayama,Mark D Wilkinson,Rutger Vos et al.
Toshiaki Katayama et al.
Background: The interaction between biological researchers and the bioinformatics tools they use is still hampered by incomplete interoperability between such tools. To ensure interoperability initiatives are effectively ...
A shortest-path graph kernel for estimating gene product semantic similarity [0.03%]
一种最短路径图核方法用于估计基因产物的语义相似性
Marco A Alvarez,Xiaojun Qi,Changhui Yan
Marco A Alvarez
Background: Existing methods for calculating semantic similarity between gene products using the Gene Ontology (GO) often rely on external resources, which are not part of the ontology. Consequently, changes in these exte...
Semantic validation of the use of SNOMED CT in HL7 clinical documents [0.03%]
SNOMED CT在HL7临床文档中使用的语义验证
Stijn Heymans,Matthew McKennirey,Joshua Phillips
Stijn Heymans
Background: The HL7 Clinical Document Architecture (CDA) constrains the HL7 Reference Information model (RIM) to specify the format of HL7-compliant clinical documents, dubbed CDA documents. The use of clinical terminolog...
Larisa N Soldatova,Andrey Rzhetsky
Larisa N Soldatova
Background: Hypotheses are now being automatically produced on an industrial scale by computers in biology, e.g. the annotation of a genome is essentially a large set of hypotheses generated by sequence similarity program...
Mining of vaccine-associated IFN-γ gene interaction networks using the Vaccine Ontology [0.03%]
基于疫苗本体的疫苗相关IFN-γ基因互作网络的挖掘
Arzucan Ozgür,Zuoshuang Xiang,Dragomir R Radev et al.
Arzucan Ozgür et al.
Background: Interferon-gamma (IFN-γ) is vital in vaccine-induced immune defense against bacterial and viral infections and tumor. Our recent study demonstrated the power of a literature-based discovery method in extracti...
Simon Jupp,Julie Klein,Joost Schanstra et al.
Simon Jupp et al.
Background: Chronic renal disease is a global health problem. The identification of suitable biomarkers could facilitate early detection and diagnosis and allow better understanding of the underlying pathology. One of the...
Stefan Schulz,Kent Spackman,Andrew James et al.
Stefan Schulz et al.
Background: The realm of pathological entities can be subdivided into pathological dispositions, pathological processes, and pathological structures. The latter are the bearer of dispositions, which can then be realized b...
Automating generation of textual class definitions from OWL to English [0.03%]
从OWL自动生成到英语的文本类定义Automation
Robert Stevens,James Malone,Sandra Williams et al.
Robert Stevens et al.
Background: Text definitions for entities within bio-ontologies are a cornerstone of the effort to gain a consensus in understanding and usage of those ontologies. Writing these definitions is, however, a considerable eff...
Paolo Ciccarese,Marco Ocana,Leyla Jael Garcia Castro et al.
Paolo Ciccarese et al.
Background: There is currently a gap between the rich and expressive collection of published biomedical ontologies, and the natural language expression of biomedical papers consumed on a daily basis by scientific research...
Alison Callahan,Michel Dumontier,Nigam H Shah
Alison Callahan
Background: Key to the success of e-Science is the ability to computationally evaluate expert-composed hypotheses for validity against experimental data. Researchers face the challenge of collecting, evaluating and integr...