Influence of L-lysine amino acid on the HIV-1 RNA replication in vitro [0.03%]
L-赖氨酸对HIV-1体外RNA复制的影响
Evgeny Vlad Butorov
Evgeny Vlad Butorov
Background: Virus replication strongly depends on host metabolic machinery and essential cellular factors, in particular, on amino acid profiles. Amino acids play an important role in the pathogenesis of all virus-related...
Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor [0.03%]
一种双苯并环辛二烯木质素作为HIV-1非核苷类逆转录酶抑制剂的鉴定
Ying-Shan Han,Wei-Lie Xiao,Hongtao Xu et al.
Ying-Shan Han et al.
Background: Due to resistance to all classes of anti-HIV drugs and drug toxicity, there is a need for the discovery and development of new anti-HIV drugs. ...
Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs [0.03%]
N-甲基卡巴胸腺嘧啶对 Guinea Pig 生殖器单纯疱疹病毒 II 型脱落和感染的疗效
David I Bernstein,Fernando J Bravo,Derek A Pullum et al.
David I Bernstein et al.
Background: Current approved nucleoside therapies for genital herpes simplex virus (HSV) infections are effective but improved therapies are needed for treatment of both acute and recurrent diseases. ...
Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives [0.03%]
一类新型尿嘧啶和脲类化合物的设计、合成及抗艾滋病病毒活性研究
Norikazu Sakakibara,Masanori Baba,Mika Okamoto et al.
Norikazu Sakakibara et al.
Background: A new series of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives were synthesized and evaluated as non-nucleoside HIV-1 reverse transcriptase inh...
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds [0.03%]
一类匹罗达韦和普瑞巴林类似物抗肠道病毒活性的研究
Angela Bernard,Céline Lacroix,Maria G Cabiddu et al.
Angela Bernard et al.
Background: The Enterovirus genus of the Picornaviridae is represented by several viral pathogens that are associated with human disease, namely Poliovirus 1, Enterovirus 71 and Rhinoviruses. Enterovirus 71 has been assoc...
Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors [0.03%]
潜伏HIV-1感染的治疗：组蛋白去乙酰化酶抑制剂的作用
Mary E Manson McManamy,Shweta Hakre,Eric M Verdin et al.
Mary E Manson McManamy et al.
Persistence of HIV-1 in latently infected CD4(+) T-cells prevents eradication in HIV-infected treated patients. Latency is characterized by a reversible silencing of transcription of integrated HIV-1. Several molecular mechanisms have been ...
Past and future. Current drugs targeting HIV-1 integrase and reverse transcriptase-associated ribonuclease H activity: single and dual active site inhibitors [0.03%]
过去与未来。针对HIV-1整合酶和逆转录酶相关RNA酶H活性的当前药物：单一作用位点和双作用位点抑制剂
Francesca Esposito,Enzo Tramontano
Francesca Esposito
Catalytic HIV type-1 (HIV-1) integrase (IN) and ribonuclease H (RNase H) domains belong to the polynucleotidyl transferase superfamily and are characterized by highly conserved motifs that coordinate two divalent Mg(2+) cations and are attr...
Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs [0.03%]
二脱氧核苷二酯前药地西他滨和吉西他滨的渗透性、稳定性和抗HIV-1活性的研究
Christine L Clouser,Laurent Bonnac,Louis M Mansky et al.
Christine L Clouser et al.
Background: Over 25 drugs have been approved for the treatment of HIV-1 replication. All but one of these drugs is delivered as an oral medication. Previous studies have demonstrated that two drugs, decitabine and gemcita...
Myristoylated derivatives of 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) bi-functional prodrugs with potent anti-HIV-1 activity and low cytotoxicity [0.03%]
具有强抗HIV-1活性和低细胞毒性的2',3'-脱氢-2',3'-双脱氧胸腺嘧啶核苷（司坦夫定）二元前药的肉豆蔻酰衍生物
Ramendra K Singh,Agnieszka Miazga,Aleksandra Dąbrowska et al.
Ramendra K Singh et al.
Background: To improve in vitro antiviral activity and selectivity of stavudine (d4T), a range of its bi-functional prodrugs, 5'-O-myristoylated derivatives, have been synthesized. ...