Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus [0.03%]
褪黑素通过减少脑部细胞凋亡、氧化应激和CD200表达，提高委内瑞拉马脑炎病毒的感染小鼠存活率
Milagros Montiel,Ernesto Bonilla,Nereida Valero et al.
Milagros Montiel et al.
Background: Pro-inflammatory and oxidative events during brain Venezuelan equine encephalitis virus infection could lead to apoptosis and induce anti-inflammatory responses (increased expression of CD200). The aim of this...
Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative [0.03%]
一种新型菲啶衍生物耐药的丙型肝炎病毒的分离与鉴定
Wataru Ito,Masaaki Toyama,Mika Okamoto et al.
Wataru Ito et al.
Background: The novel phenanthridinone derivative HA-719 has recently been identified as a highly potent and selective inhibitor of hepatitis C virus replication. To elucidate its mechanism of inhibition, we have isolated...
Combination activity of neuraminidase inhibitor oseltamivir and α-tocopherol in influenza virus A (H3N2) infection in mice [0.03%]
奥司他韦和α-生育酚联合对抗小鼠甲型流感病毒（H3N2）感染的活性研究
Angel S Galabov,Milka Mileva,Lora Simeonova et al.
Angel S Galabov et al.
Background: Influenza is a highly contagious viral infection of the respiratory system. To attack two processes involved in flu pathogenesis-viral replication in the infected body and oxidative damages, we studied the com...
Predicting Zika virus structural biology: Challenges and opportunities for intervention [0.03%]
寨卡病毒结构生物学预测：介入面临的挑战与机遇
Bryan D Cox,Richard A Stanton,Raymond F Schinazi
Bryan D Cox
Background: Zika virus is an emerging crisis as infection is implicated in severe neurological disorders-Guillain-Barré syndrome and fetal microcephaly. There are currently no treatment options available for Zika virus i...
Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection [0.03%]
乌术酸衍生物可抑制广谱的流感病毒并保护小鼠免受致死剂量的流感病毒感染
A A Shtro,V V Zarubaev,O A Luzina et al.
A A Shtro et al.
Background: Influenza is a disease of significant morbidity and mortality, the number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains. In this work, we demonstrate activity of ...
Molecular basis of influenza hemagglutinin inhibition with an entry-blocker peptide by computational docking and mass spectrometry [0.03%]
计算对接和质谱鉴定的入胞阻断肽抑制流感病毒血凝素的分子机制研究
Robert Lu,Patrick Müller,Kevin M Downard
Robert Lu
Background: The increased resistance of circulating strains to current antiviral inhibitors of the influenza virus necessitates that new antivirals and their mode of action are identified. Influenza hemagglutinin is an id...
Anti-HIV-1 activity determined by β-galactosidase activity in the multinuclear activation of an indicator assay is comparable with that by a conventional focus counting method [0.03%]
用多核激活报告基因试验的β-半乳糖苷酶活性测定的抗HIV-1活性与传统的焦点计数法一致
Fusako Miyamoto,Kumi Kawaji,Shinya Oishi et al.
Fusako Miyamoto et al.
Background: Direct comparison of enzymatic and original blue cell-counting detections with the multinuclear activation of an indicator (MAGI) cells, so far, remains to be performed in parallel. Although inhibitors for rev...
Comparative Study
Antiviral chemistry & chemotherapy. 2015 Apr;24(2):77-82. DOI:10.1177/2040206615614164 2015
Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives [0.03%]
1-取代的三氮唑并苯环类化合物的设计、合成及抗HIV活性研究
Norikazu Sakakibara,Gianfranco Balboni,Cenzo Congiu et al.
Norikazu Sakakibara et al.
Background: The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is an attractive target for the development of drugs used in the treatment of HIV-1 infection and acquired immune deficiency syndro...
Milka Yanachkova,Wei-Chu Xu,Sofya Dvoskin et al.
Milka Yanachkova et al.
Background: Because guanine-based herpes simplex virus thymidine kinase inhibitors are not orally available, we synthesized various 6-deoxy prodrugs of these compounds and evaluated them with regard to solubility in water...
A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice [0.03%]
高剂量整合酶抑制剂两周疗程不会导致小鼠肾毒性
Michael T Eadon,Hongji Zhang,Todd C Skaar et al.
Michael T Eadon et al.
Background: The integrase inhibitors, raltegravir and dolutegravir, are nucleoside reverse transcriptase inhibitor-sparing agents which may be used as part of first-line antiretroviral therapy for HIV. These drugs inhibit...