Angel S Galabov,Lucia Mukova,Yuriy P Abashev et al.
Angel S Galabov et al.
This review describes the contemporary state of research for antivirals effective against flaviviruses, especially focusing on inhibitors of the pestivirus causative agent of bovine viral diarrhoea virus. We highlight cycluridine, an origin...
Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities [0.03%]
代谢重构可为乙肝疾病的诊断与治疗提供新思路
Jesse Jr Masson,Hugh Ww Billings,Clovis S Palmer
Jesse Jr Masson
Metabolic remodeling occurs in immune cells during an infection. Host cells must upregulate energy production for growth, proliferation, and effector functions to limit the damage imposed by pathogens. One example, the hepatitis B virus, in...
Andrea Brancale
Andrea Brancale
Biswajit G Roy
Biswajit G Roy
Various viral diseases, such as acquired immunodeficiency syndrome, influenza, and hepatitis, have emerged as leading causes of human death worldwide. Scientific endeavor since invention of DNA-dependent RNA polymerase of pox virus in 1967 ...
Equilibrative nucleoside transporter 1 expression in primary human hepatocytes is highly variable and determines uptake of ribavirin [0.03%]
人源性原代肝细胞中核苷转运体1的表达具有高度可变性并决定利巴韦林的摄取能力
Kanwal Baloch,Liqiong Chen,Ameer A Memon et al.
Kanwal Baloch et al.
Aims Ribavirin is a nucleoside analogue and remains a necessary component of both interferon-based and directly acting anti-viral regimens for the treatment of hepatitis C virus infection. The achievable concentration of ribavirin within he...
Andrea Brancale
Andrea Brancale
Combinations of L-NG-monomethyl-arginine and oseltamivir against pandemic influenza A virus infections in mice [0.03%]
L-NG-单甲基精氨酸与奥司他韦联合抗流感病毒肺炎的小鼠实验研究
Donald F Smee,Ashley Dagley,E B Tarbet
Donald F Smee
L-NG-monomethyl-arginine (L-NMMA) is an experimental compound that suppresses nitric oxide production in animals. The compound was combined with oseltamivir to treat lethal influenza A/California/04/2009 (H1N1) pandemic virus infections in ...
Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents [0.03%]
新型对称联苯二胺抗丙型肝炎病毒活性研究
Marcella Bassetto,Salvatore Ferla,Pieter Leyssen et al.
Marcella Bassetto et al.
Background: Despite the great progress made in the last 10 years, alternative strategies might help improving definitive treatment options against hepatitis C virus infection. ...
Anti-enteroviral triple combination of viral replication inhibitors: activity against coxsackievirus B1 neuroinfection in mice [0.03%]
抗肠病毒的三种复制抑制剂联合疗法对柯萨奇B1病毒神经感染小鼠的活性研究
Adelina Stoyanova,Ivanka Nikolova,Gerhard Pürstinger et al.
Adelina Stoyanova et al.
Background: Chemotherapy is an important tool for controlling enterovirus infections, but clinically effective anti-enterovirus drugs do not currently exist, mainly due to the development of drug resistance. We investigat...
Effect of sialidase fusion protein (DAS 181) on human metapneumovirus infection of Hep-2 cells [0.03%]
sialidase融合蛋白(DAS181)对人副流感病毒3型感染Hep-2细胞的影响
Sutthiwan Thammawat,Tania A Sadlon,Penelope Adamson et al.
Sutthiwan Thammawat et al.
Methods: Hep-2 cells were preincubated with DAS181 or control DAS185 (a mutated sialidase) prior to inoculation with human metapneumovirus strains. Infectivity was assessed by a cell-based ELISA quantitating human metapne...