Joy Y Feng
Joy Y Feng
Nucleoside and nucleotide analogs have played significant roles in antiviral therapies and are valued for their impressive potency and high barrier to resistance. They have been approved for treatment of herpes simplex virus-1, HIV, HBV, HC...
Katherine Seley-Radtke
Katherine Seley-Radtke
Over the past few years, nucleosides have maintained a prominent role as one of the cornerstones of antiviral and anticancer therapeutics, and many approaches to nucleoside drug design have been pursued. One such approach involves flexibili...
Current and future use of nucleo(s)tide prodrugs in the treatment of hepatitis C virus infection [0.03%]
核酸（苷）前药在治疗丙型肝炎病毒感染中的应用及展望
Cyril B Dousson
Cyril B Dousson
This review describes the current state of discovery of past most important nucleoside and nucleotide prodrugs in the treatment of hepatitis C virus infection as well as future potential drugs currently in discovery or clinical evaluation. ...
Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine [0.03%]
9-（2-磷onomethoxy）乙基腺嘌呤的新式二磷酸类似物的合成及其对HIV-1逆转录酶底物性质的研究
Wolfgang Hg Laux,Stéphane Priet,Karine Alvarez et al.
Wolfgang Hg Laux et al.
Background The replacement of β,γ-pyrophosphate by β,γ-phosphonate moieties within the triphosphate chain of 5'-triphosphate nucleoside analogues was previously studied for various antiviral nucleoside analogues such as AZT and 2',3'-di...
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors [0.03%]
吲哚芳基砜类化合物：一类高效人免疫缺陷病毒非核苷逆转录酶抑制剂的发现及研究
Valeria Famiglini,Romano Silvestri
Valeria Famiglini
Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 dis...
Polarized macrophage subsets differentially express the drug efflux transporters MRP1 and BCRP, resulting in altered HIV production [0.03%]
极化型巨噬细胞亚群差异性表达药物外排转运蛋白MRP1和BCRP，导致HIV产生量改变
Hui He,Merrion Buckley,Bernard Britton et al.
Hui He et al.
Introduction Macrophages play an important role in HIV, where they are a cellular reservoir. Macrophages are polarized into two phenotypes: pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages, which may have altered express...
Xue-Qiang Yin,Stewart W Schneller
Xue-Qiang Yin
Objective To synthesize 3,7-dideazaneplanocin and evaluate its antiviral potential. Methods The target 3,7-dideazaneplanocin has been prepared in five steps from a readily available cyclopentenol. A thorough in vitro antiviral analysis was ...
Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors [0.03%]
建立抗病毒药效筛选系统及输入性肺炎病毒抑制剂的鉴定
Masanori Baba,Masaaki Toyama,Norikazu Sakakibara et al.
Masanori Baba et al.
Aims Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan. The causative virus severe fever with thrombocytopenia syndrome vi...
Nucleoside diphosphate and triphosphate prodrugs - An unsolvable task? [0.03%]
核苷二磷酸和三磷酸前药-一个无法完成的任务？
Chris Meier
Chris Meier
In this review, our recent advances in the development of nucleoside di- and nucleoside triphosphate prodrugs is summarized. Previously, we had developed a successful membrane-permeable pronucleotide system for the intracellular delivery of...
Investigation of the solvent-dependent photolysis of a nonnucleoside reverse-transcriptase inhibitor, antiviral agent efavirenz [0.03%]
溶剂依赖性光解作用对非核苷类逆转录酶抑制剂、抗病毒药物依发韦仑的研究
Maryam A Jordaan,Michael Shapi
Maryam A Jordaan
This study sought to investigate the solvent-dependency on the photolysis of efavirenz to gain insight into the photoprocesses involved. The primary mechanisms were firstly the excited-state intramolecular proton transfer (i.e. phototautome...