Genome analysis of coxsackievirus B1 isolates during the consecutive alternating administration course of triple antiviral combination in newborn mice [0.03%]
连续交替给予三种抗病毒药物组合期间新生小鼠中柯萨奇B1病毒分离株的基因组分析
Petar Grozdanov,Marie-Line Joffret,Adelina Stoyanova et al.
Petar Grozdanov et al.
Background: We developed a new approach for the treatment of enterovirus infections, the consecutive alternating administration (CAA) of a combination of enterovirus inhibitors. On the model of coxsackievirus B1 (CVB1) in...
Incidence of CXCR4 tropism and CCR5-tropic resistance in treatment-experienced participants receiving maraviroc in the 48-week MOTIVATE 1 and 2 trials [0.03%]
马拉韦罗治疗经治患者48周的MOTIVATE-1和MOTIVATE-2试验中CCR5嗜性和CXCR4嗜性及对CCR5拮抗剂产生耐药患者的检出率
Becky Jubb,Marilyn Lewis,Lynn McFadyen et al.
Becky Jubb et al.
Maraviroc blocks HIV-1 entry into CD4+ cells by interrupting the interaction between viral gp120 and cell-surface CCR5. Resistance to CCR5 antagonist–mediated inhibition can develop by unmasking pre-existing CXCR4-using virus or through se...
Relevance of Ebola virus VP35 homo-dimerization on the type I interferon cascade inhibition [0.03%]
埃博拉病毒VP35同源二聚化对其抑制I型干扰素信号通路的 relevance
Francesco Di Palma,Gian Luca Daino,Venkata Krishnan Ramaswamy et al.
Francesco Di Palma et al.
Ebola virus high lethality relies on its ability to efficiently bypass the host innate antiviral response, which senses the viral dsRNA through the RIG-I receptor and induces type I interferon α/β production. In the bypassing action, the ...
Synthesis of multi ring-fused imidazo [1,2- a]isoquinoline-based fluorescent scaffold as anti-Herpetic agent [0.03%]
合成多环融合咪唑并[1,2-a]异喹啉类荧光骨架作为抗疱疹药物的研究
Harapriya Chakravarty,Durbadal Ojha,Ananda K Konreddy et al.
Harapriya Chakravarty et al.
Background: Natural product-inspired synthesis is a key incorporation in modern diversity-oriented synthesis to yield biologically novel scaffold. Inspired by β-carboline fused system, we have designed molecules with mul...
Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors [0.03%]
作为非核苷类逆转录酶抑制剂的取代（o，o-二氟苯基）联嘧啶的合成及其抗人类免疫缺陷病毒活性研究
Lucie Čechová,Milan Dejmek,Ondřej Baszczyňski et al.
Lucie Čechová et al.
With the worldwide number of human immunodeficiency virus positive patients stagnant and the increasing emergence of viral strains resistant to current treatment, the development of novel anti-human immunodeficiency virus drug candidates is...
Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration [0.03%]
莫 zo 布 尔 （plerixafor，AMD3100）——美國 食 品 與 濫 用 物 辯 議 批 准 10 年 纪念
Erik De Clercq
Erik De Clercq
AMD3100 (plerixafor, Mozobil®) was first identified as an anti-HIV agent specifically active against the T4-lymphotropic HIV strains, as it selectively blocked the CXCR4 receptor. Through interference with the interaction of CXCR4 with its...
Jennifer C Becker,Sharon J Tollefson,David Weaver et al.
Jennifer C Becker et al.
Human metapneumovirus, a paramyxovirus discovered in 2001, is a major cause of lower respiratory infection in adults and children worldwide. There are no licensed vaccines or drugs for human metapneumovirus. We developed a fluorescent, cell...
Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus [0.03%]
一类具有抗人单纯疱疹病毒和水痘带状疱疹病毒活性的嘌呤类非环状核苷膦酸盐化合物
Ondřej Baszczyňski,Martin Maxmilian Kaiser,Michal Česnek et al.
Ondřej Baszczyňski et al.
While noncanonic xanthine nucleotides XMP/dXMP play an important role in balancing and maintaining intracellular purine nucleotide pool as well as in potential mutagenesis, surprisingly, acyclic nucleoside phosphonates bearing a xanthine nu...
Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells [0.03%]
恩沙米윰（异烟酸衍生物）对分化的人正常支气管上皮细胞中流感病毒的活性作用
David Boltz,Xinjian Peng,Miguel Muzzio et al.
David Boltz et al.
Aims: New therapeutics for the control of influenza virus infections are needed to alleviate the burden caused by seasonal epidemics and occasional pandemics, and to overcome the potential risk of drug-resistance emergenc...
Cyclophilin A as a target in the treatment of cytomegalovirus infections [0.03%]
环磷肽酶A作为治疗巨细胞病毒感染靶点的研究
Ashwaq A Abdullah,Rasedee Abdullah,Zeenathul A Nazariah et al.
Ashwaq A Abdullah et al.
Background: Viruses are obligate parasites that depend on the cellular machinery of the host to regenerate and manufacture their proteins. Most antiviral drugs on the market today target viral proteins. However, the more ...