Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections [0.03%]
针对病毒基因组合成的广谱抗RNA病毒感染策略
Johanna Huchting
Johanna Huchting
Zoonotic spillover, i.e. pathogen transmission from animal to human, has repeatedly introduced RNA viruses into the human population. In some cases, where these viruses were then efficiently transmitted between humans, they caused large dis...
Real-world single-center experience with direct-acting antivirals for improvement of the liver fibrosis after chronic hepatitis C treatment [0.03%]
直接抗病毒药物治疗慢性丙型肝炎后肝脏纤维化改善的现实世界单中心经验
Sun Hee Lee,Hyun Phil Shin,Joung Il Lee
Sun Hee Lee
Background: Recently, new direct-acting antivirals (DAAs) are known to eradicate chronic hepatitis C (CHC) virus infection and prevent the progression of liver fibrosis. Liver fibrosis may predispose to liver cirrhosis or...
Katherine Seley-Radtke
Katherine Seley-Radtke
Clinical evidences on the antiviral properties of macrolide antibiotics in the COVID-19 era and beyond [0.03%]
新冠时代及以后大环内酯类抗生素抗病毒特性的临床证据
Dimitri Poddighe,Mohamad Aljofan
Dimitri Poddighe
Macrolides are a large group of antibiotics characterised by the presence of a macro-lactone ring of variable size. The prototype of macrolide antibiotics, erythromycin was first produced by Streptomyces and associated species more than hal...
Spectrum of antiviral activity of 4-aminopyrimidine N-oxides against a broad panel of tick-borne encephalitis virus strains [0.03%]
4-氨基嘧啶N-氧化物对一组广泛的蜱传脑炎病毒株的广谱抗病毒活性
Evgenia V Dueva,Ksenia K Tuchynskaya,Liubov I Kozlovskaya et al.
Evgenia V Dueva et al.
Tick-borne encephalitis is an important human arbovirus neuroinfection spread across the Northern Eurasia. Inhibitors of tick-borne encephalitis virus (TBEV) strain Absettarov, presumably targeting E protein n-octyl-β-d-glucoside (β-OG) p...
Respiratory syntycial virus: Current treatment strategies and vaccine approaches [0.03%]
呼吸道合胞病毒：目前的治疗策略和疫苗研究路径
Elena Margret Thornhill,Jessica Salpor,David Verhoeven
Elena Margret Thornhill
Respiratory Syncytial Virus is a yearly respiratory virus that causes significant frequencies of morbidities, particularly in the young and elderly populations. However, preventive vaccines and/or treatment therapies are generally lacking, ...
Virologic failure after 48 weeks of raltegravir-based regimen in low HIV-1 incidence setting [0.03%]
低HIV-1发病率人群中拉替拉韦为基础方案治疗48周后的病毒学失败
Wassim Chehadeh,Osama Albaksami,Shaikhah Al-Shammari
Wassim Chehadeh
Background: With the advent of next generation integrase strand transfer inhibitors, the rates of virologic failure in treated subjects are expected to decrease. In this study, we analyzed the mutation patterns leading to...
Nucleos(t)ide analogues and Hepatitis B virus-related hepatocellular carcinoma: A literature review [0.03%]
核苷(酸)类似物与乙肝病毒相关肝细胞癌的研究进展综述
Mohamed A Abd El Aziz,Rodolfo Sacco,Antonio Facciorusso
Mohamed A Abd El Aziz
Hepatitis B virus is mainly considered to cause hepatocellular carcinoma which is the fourth leading cause of cancer-related mortality worldwide. Treatment of Hepatitis B virus with nucleos(t)ide analogues can decrease the progression of th...
Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir [0.03%]
人淋巴细胞对人腺病毒19型抗病毒药物评价的应用：扎西他宾的活性优于西多福韦
Kohsuke Nakagawara,Hironori Hayashi,Kumi Kawaji et al.
Kohsuke Nakagawara et al.
Human adenovirus type 19 (HAdV-19) is a major cause of the epidemic keratoconjunctivitis. Outbreaks of keratoconjunctivitis are problematic to human health, especially for infants, the elderly, and immunocompromised individuals. However, th...
In vitro anti-adenoviral activities of ethanol extract, fractions, and main phenolic compounds of pomegranate (Punica granatum L.) peel [0.03%]
番石榴皮的乙醇提取物、组分和主要酚类化合物的抗腺病毒活性研究
Ali Karimi,Mohammad-Taghi Moradi,Mohammad Rabiei et al.
Ali Karimi et al.
Background: Adenovirus causes a number of diseases in human, and can cause serious infection in severely immunosuppressed individuals. Despite the seriousness of adenovirus infection, there is no definitely approved anti-...