Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Early mechanistic studies [0.03%]
使用小鼠诺如病毒评估细胞培养中的抗诺如病毒活性：早期机制研究
Jana Van Dycke,Jasper Rymenants,Johan Neyts et al.
Jana Van Dycke et al.
Human norovirus is the main cause of viral gastroenteritis, resulting annually in ∼ 700 million infections and 200,000 deaths, of whom most are children
Insights into bioinformatic approaches for repurposing compounds as anti-viral drugs [0.03%]
关于计算方法重定位化合物作为抗病毒药物的见解
Wenxiao Zheng,Leonardo D&#x;Aiuto,Matthew J Demers et al.
Wenxiao Zheng et al.
Background: Drug repurposing is a cost-effective strategy to identify drugs with novel effects. We searched for drugs exhibiting inhibitory activity to Herpes Simplex virus 1 (HSV-1). Our strategy utilized gene expression...
Screening and in vitro antiviral assessment of small molecules against fluorescent protein-expressing Bunyamwera virus in a cell-based assay using high-content imaging [0.03%]
一种基于细胞的高内涵成像测定法筛选 bunyamwera 病毒荧光蛋白表达株的抗病毒小分子及其在体外的抗病毒活性评估
Sebastiaan Ter Horst,Winston Chiu,Johan Neyts et al.
Sebastiaan Ter Horst et al.
Many species of the order Bunyavirales contain potentially fatal viruses that lack effective medical countermeasures and are therefore collectively a major public health threat. Here, we describe a cell-based assay using Bunyamwera virus (B...
V3-Loop genotypes do not predict maraviroc susceptibility of CCR5-tropic virus or clinical response through week 48 in HIV-1-infected, treatment-experienced persons receiving optimized background regimens [0.03%]
V3-Loop基因型不能预测CCR5嗜性病毒对玛拉维若的敏感度或治疗经验HIV-1感染者在接受优化背景疗法至第48周时的临床应答情况
M E Lewis,P Simpson,J Mori et al.
M E Lewis et al.
Viruses from 15 of 35 maraviroc-treated participants with virologic failure and CCR5-tropic (R5) virus in the MOTIVATE studies at Week 24 had reduced maraviroc susceptibility. On-treatment amino acid changes were observed in the viral envel...
Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Identification of active compounds [0.03%]
基于鼠诺如病毒细胞培养体系的抗诺如病毒活性评价及有效化合物筛选
Jana Van Dycke,Jasper Rymenants,Johan Neyts et al.
Jana Van Dycke et al.
Human norovirus is the main cause of viral gastroenteritis, resulting annually in ∼ 700 million infections and 200,000 deaths, of whom most are children
Memantine treatment reduces the incidence of flaccid paralysis in a zika virus mouse model of temporary paralysis with similarities to Guillain-Barré syndrome [0.03%]
美金刚治疗可减少ZIKV诱导的小鼠临时性瘫痪模型中弛缓性瘫痪的发生率：与吉兰-巴雷综合征的相似性
Venkatraman Siddharthan,Hong Wang,Alexandre Lr de Oliveira et al.
Venkatraman Siddharthan et al.
Clinical evidence suggests that Zika virus contributes to Guillain-Barré syndrome that causes temporary paralysis. We utilized a recently described Zika virus mouse model of temporary flaccid paralysis to address the hypothesis that treatm...
Highly prevalent Russian HIV-1 V3-loop sequence variants are susceptible to maraviroc [0.03%]
一种在俄罗斯广泛流行的HIV-1病毒序列变异体对马拉维若敏感
M E Lewis,B Jubb,P Simpson et al.
M E Lewis et al.
Introduction: Maraviroc inhibits CCR5-tropic HIV-1 across different subtypes in vitro and has demonstrated efficacy in clinical trials. V3-loop amino acid variants observed in individual maraviroc-resistant viruses have n...
Killing HIV-infected resting central memory CD4+ T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy [0.03%]
通过靶向抑制凋亡蛋白抑制的自噬来杀伤HIV感染的静止中央记忆CD4+T细胞
Gang Zhang,Xing Huang
Gang Zhang
Dysfunction of CD4+ T cells by HIV infection can cause serious immune defects. Recently, Campbell and colleagues described an intriguing and simple therapeutic method for HIV-infected resting central memory CD4+ T cells (HIV-TCM), dependent...
Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective [0.03%]
非洲植物化学成分中生物碱和黄酮作为SARS-Cov-2依赖RNA聚合酶抑制剂的潜在抑制剂：基于计算方法研究
Oludare M Ogunyemi,Gideon A Gyebi,Abdo A Elfiky et al.
Oludare M Ogunyemi et al.
Corona Virus Disease 2019 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Exploiting the potentials of phytocompounds is an integral component of the international response to this pandemic. ...
Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19 [0.03%]
独一味对SARS-CoV-2的体外抗病毒活性及其治疗COVID-19的潜力
Lawrence R Bernstein,Leike Zhang
Lawrence R Bernstein
Background: Gallium has demonstrated strong anti-inflammatory activity in numerous animal studies, and has also demonstrated direct antiviral activity against the influenza A H1N1 virus and the human immunodeficiency viru...