Mesoionic heterocyclic compounds as candidate messenger RNA cap analogue inhibitors of the influenza virus RNA polymerase cap-binding activity [0.03%]
作为流感病毒RNA聚合酶帽结合活性抑制剂的介离子杂环化合物-一类信使核糖核酸“帽”类似物候选药物
Ian Mickleburgh,Feng Geng,Laurence Tiley
Ian Mickleburgh
Background: An unusual feature of influenza viral -messenger RNA (mRNA) synthesis is its dependence upon host cell mRNAs as a source of capped RNA primers. A crucial activity of the influenza polymerase is to steal these ...
Synthesis and antiviral evaluation of 4'-alkoxy analogues of 9-(beta-D-xylofuranosyl)adenine [0.03%]
9-(β-D-木糖呋喃基)腺嘌呤的4'-烷氧类似物的合成与抗病毒评价
Yutaka Kubota,Nobuhide Ishizaki,Yuri Kaneda et al.
Yutaka Kubota et al.
Background: Motivated by the reported biological activity of 9-(beta-D-xylofuranosyl)adenine (xylo-A), the synthesis of its 4'-alkoxy analogues was carried out. ...
Hans-Jürgen Stellbrink
Hans-Jürgen Stellbrink
Despite the recent licensure of several new antiretroviral compounds, there is still a need to develop additional agents. Problems with antiviral activity, tolerability, ease of administration, extent of cross-resistance and pharmacokinetic...
Jason D Graci,Joseph M Colacino,Stuart W Peltz et al.
Jason D Graci et al.
HIV type-1 (HIV-1) can establish a state of latency in infected patients, most notably in resting CD4(+) T-cells. This long-lived reservoir allows for rapid re-emergence of viraemia upon cessation of highly active antiretroviral therapy, ev...