Antiretroviral therapy in macrophages: implication for HIV eradication [0.03%]
抗逆转录病毒疗法对巨噬细胞的影响：对艾滋病根除的意义
Christina Gavegnano,Raymond F Schinazi
Christina Gavegnano
HIV type-1 (HIV-1) accounts for more than 25 million deaths and nearly 40 million people are infected worldwide. A significant obstacle in clearing virus from infected individuals is latently infected viral reservoirs. Latent HIV-1 can emer...
Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560 [0.03%]
抗牛病毒性腹泻病毒和丙型肝炎病毒的环氧化酶抑制剂SC-560的作用
Mika Okamoto,Masashi Sakai,Yukinori Goto et al.
Mika Okamoto et al.
Background: A number of compounds were examined for their inhibitory effect on bovine viral diarrhoea virus (BVDV) replication in cell cultures and found that some cyclooxygenase (COX) inhibitors had antiviral activity ag...
Zhimeng Wu,John C Drach,Mark N Prichard et al.
Zhimeng Wu et al.
Background: Following the example of L-valine prodrugs of antiviral nucleoside analogues, L-valine ester of cyclopropavir (valcyclopropavir) was synthesized. ...
Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor [0.03%]
三羧基茋酸是一种高效的抗HCV复制抑制剂及其作用机制研究
Ye Chen,Alain Bopda-Waffo,Amartya Basu et al.
Ye Chen et al.
Background: Hepatitis C virus (HCV) NS5B is an essential component of the viral replication machinery and an important target for antiviral intervention. Aurintricarboxylic acid (ATA), a broad-spectrum antiviral agent, wa...
Wei Pang,Siu-Cheung Tam,Yong-Tang Zheng
Wei Pang
There are now 26 antiretroviral drugs and 6 fixed-dose combinations, including reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors and fusion (or entry) inhibitors, approved by the US Food and Drug Administration for...
Effect of duration and intensity of ganciclovir exposure on lymphoblastoid cell toxicity [0.03%]
更昔洛韦暴露时间和剂量对淋巴母细胞毒性的效应
Audrey Janoly-Dumenil,Isabelle Rouvet,Nathalie Bleyzac et al.
Audrey Janoly-Dumenil et al.
Introduction: Human cytomegalovirus infection is still a major complication after pediatric bone marrow transplantation and could be fatal in some cases. The toxicity of the drug in dividing transplanted haematopoietic ce...
Ryan C Fink,Bill Roschek Jr,Randall S Alberte
Ryan C Fink
Background: The development of antiviral drugs has provided crucial new means to mitigate or relieve the debilitating effects of many viral pathogens. Regular use of these drugs has led to generation of resistant strains,...
Sulfated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity [0.03%]
海藻Sebdenia polydactyla中的硫酸木糖甘露聚糖的结构特征、化学修饰和抗病毒活性
Tuhin Ghosh,Carlos Alberto Pujol,Elsa Beatriz Damonte et al.
Tuhin Ghosh et al.
Background: Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral th...
RNA-interference-based gene therapy approaches to HIV type-1 treatment: tackling the hurdles from bench to bedside [0.03%]
基于RNA干扰的基因治疗策略用于人类免疫缺陷病毒1型感染的治疗：从实验室到临床的挑战
Karin J von Eije,Ben Berkhout
Karin J von Eije
RNA interference (RNAi) is a cellular mechanism that can be induced by small interfering RNAs (siRNAs) to mediate sequence-specific gene silencing by cleavage of the targeted messenger RNA. RNAi can be used as an antiviral approach to silen...
Hugh J Field,Melissa N Galea
Hugh J Field