Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132 [0.03%]
热休克蛋白90抑制剂17-AAG和蛋白酶体抑制剂MG132联合治疗丙型肝炎病毒感染
Saneyuki Ujino,Saori Yamaguchi,Kunitada Shimotohno et al.
Saneyuki Ujino et al.
Background: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Here, we report a new and effective strategy for inhibiting HCV replication using an inhibitor of heat-shock protein 90, 17-AAG (17-...
The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides [0.03%]
一系列5-三甲基硅烷-1-β-d-（阿拉伯糖呋喃糖）尿苷磷酸酰胺酯ProTides的设计、合成及抗病毒活性研究
Youcef Mehellou,Jan Balzarini,Christopher McGuigan
Youcef Mehellou
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a particular limitation for uridine-based nucleosides. Our ProTide method allows the direct use of masked membrane-soluble p...
Nicola Zonta,Antonio Coluccia,Andrea Brancale
Nicola Zonta
Computer-aided drug design has seen constantly increasing application over the past two decades in every area of drug discovery. It can offer significant advantages over conventional approaches, being far less expensive and faster than conv...
Activity of isatine-sulfadimidine derivatives against 2009 pandemic H1N1 influenza virus in cell culture [0.03%]
异硫酸二甲氧inine衍生物对2009年H1N1流感病毒的细胞培养活性
Periyasamy Selvam,Markandavel Chandramohan,Brett L Hurst et al.
Periyasamy Selvam et al.
Background: The development of antiviral drugs has provided crucial new means to mitigate or relieve the debilitating effects of many viral pathogens. New classes of inhibitors are essential to combat swine influenza vira...
The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties [0.03%]
环周期蛋白依赖性激酶抑制剂Olomoucine II具有抗病毒特性
Jitka Holcakova,Peter Tomasec,Joachim J Bugert et al.
Jitka Holcakova et al.
Background: Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective ant...
Factors affecting template usage in the development of K65R resistance in subtype C variants of HIV type-1 [0.03%]
影响HIV-1型C亚型开发K65R抗性的模板使用因素
Dimitrios Coutsinos,Cédric F Invernizzi,Hongtao Xu et al.
Dimitrios Coutsinos et al.
Background: We have shown that the K65R resistance mutation in HIV type-1 (HIV-1) reverse transcriptase (RT) is selected more rapidly in subtype C than subtype B HIV-1 in biochemical, cell culture and clinical studies. Te...
FV-100: the most potent and selective anti-varicella zoster virus agent reported to date [0.03%]
FV-100：迄今为止报道的最强和选择性最高的抗水痘带状疱疹病毒剂
Marco Migliore
Marco Migliore
Bicyclic aryl furano pyrimidines represent the most potent anti-varicella zoster virus (VZV) agents reported to date. Lead compounds have 50% effective concentration (EC(50)) values in vitro that are in the subnanomolar range and selectivit...
Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs [0.03%]
新型β-D-2'-C-甲基-4'-叠氮嘧啶核糖苷磷酰胺前药对丙型肝炎病毒的抗病毒活性
Ramu Rondla,Steven J Coats,Tamara R McBrayer et al.
Ramu Rondla et al.
Background: 2'-C-methyl and 4'-azido nucleosides have previously demonstrated inhibition of hepatitis C virus (HCV) replication by targeting the RNA-dependent RNA polymerase NS5B. In an effort to discover new and more pot...
Ira Yudovin-Farber,Irina Gurt,Ronen Hope et al.
Ira Yudovin-Farber et al.
Background: Herpes simplex virus (HSV) establishes latent infection in humans with periodic reactivation. Acyclovir, valacyclovir and foscarnet are in medical use today against HSV type-1 (HSV-1) and type-2 (HSV-2), inhib...
Kazuya Shimura,Eiichi N Kodama
Kazuya Shimura
Integration is a distinctive and essential process in the HIV infection cycle and thus represents an attractive antiviral drug target. Integrase inhibitors combined with other classes of drug might contribute to long-lasting suppression of ...