James J McSharry,George L Drusano
James J McSharry
Pharmacodynamic investigation of antiviral compounds studies the relationship between drug exposure and the virological response. These studies are usually performed in animals and, eventually, in humans and are a very expensive proposition...
Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates [0.03%]
核苷5'-O-(N-酰基)磷酰胺的合成及其抗病毒活性评价
Katarzyna Kulik,Ewa Radzikowska,Renata Kaczmarek et al.
Katarzyna Kulik et al.
Background: pyrimidine nucleoside analogues represent an established class of clinically useful antiviral agents. Once inside the cell, they are activated by a series of intracellular phosphorylation steps to produce 5´-...
Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: bisphenylboronic acids [0.03%]
基于苯基硼酸的糖结合抗病毒药物：双苯基硼酸化合物
Paul C Trippier,Jan Balzarini,Christopher McGuigan
Paul C Trippier
Background: carbohydrate-binding agents are considered as potential therapeutic agents for the inhibition of highly glycosylated enveloped viruses such as HIV type-1. Phenylboronic acids are well-known to bind the cis-dio...
Darrell R Davis,Punit P Seth
Darrell R Davis
HCV infection is a significant human disease, leading to liver cirrhosis and cancer, and killing >10,000 people in the US annually. Translation of the viral RNA genome is initiated by ribosomal binding to a highly structured RNA element, th...
Justin G Julander,Stuart T Perry,Sujan Shresta
Justin G Julander
There are currently no licensed antivirals available for the treatment of dengue virus (DENV), which causes significant morbidity and mortality throughout tropical areas of the world and is now encroaching on the southern United States. Rec...
Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture [0.03%]
类 helioxanthin 化合物 8-1 对鸭乙型肝炎病毒的抑制作用
Chunxiao Ying,Shenglan Tan,Yung-Chi Cheng
Chunxiao Ying
Background: Current approved anti-HBV treatment cannot completely eliminate HBV infection, and emergence of resistant virus is an important treatment issue. Effective anti-HBV agents with different mechanisms of action on...
Anti-cytomegalovirus activity of sulfated glucans generated from a commercial preparation of rice bran [0.03%]
一种商业稻米麸皮制剂产生的硫酸化糖复合物的抗巨细胞病毒活性
Tuhin Ghosh,Sabrina Auerochs,Sudipta Saha et al.
Tuhin Ghosh et al.
Background: Many viruses display affinity for polysaccharides presented at the surface of target cells with high biological relevance for virus attachment and entry. This raises the possibility of the application of polys...
Laninamivir and its prodrug, CS-8958: long-acting neuraminidase inhibitors for the treatment of influenza [0.03%]
laninamivir及其前药CS-8958：治疗流感的长效神经氨酸酶抑制剂
Makoto Yamashita
Makoto Yamashita
Oseltamivir and zanamivir are currently licensed worldwide for influenza treatment and chemoprophylaxis. Both drugs require twice-daily administration for 5 days for treatment. A new influenza drug, laninamivir (code name R-125489), and its...
David Lembo,Roberta Cavalli
David Lembo
Nanomedicine opens new therapeutic avenues for attacking viral diseases and for improving treatment success rates. Nanoparticulate-based systems might change the release kinetics of antivirals, increase their bioavailability, improve their ...
In vitro and in vivo anti-influenza virus activity of diarylheptanoids isolated from Alpinia officinarum [0.03%]
从姜黄中分离的日芳庚内酯类化合物的抗流感病毒活性研究
Rie Sawamura,Tomomi Shimizu,Yi Sun et al.
Rie Sawamura et al.
Background: Diarylheptanoids (AO-0002 [7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-4E-hepten-3-one] and AO-0011 [(5S)-5-hydroxy-7-(4''-hydroxyphenyl)-1-phenyl-3-heptanone]) isolated from Alpinia officinarum have been repor...