Epigallocatechin gallate inhibits the HIV reverse transcription step [0.03%]
表没食子儿茶素没食子酸酯抑制HIV的逆转录步骤
Shenwei Li,Toshio Hattori,Eiichi N Kodama
Shenwei Li
Background: Epigallocatechin gallate (EGCG), the most abundant catechin in green tea, has been reported to inhibit HIV-1 replication prior to its integration into host DNA via various proposed mechanisms; however, the spe...
Effects of TheraMax on influenza virus infections in cell culture and in mice [0.03%]
TheraMax抗流感病毒感染的细胞与动物实验研究
Donald F Smee,Brett L Hurst,Min-Hui Wong
Donald F Smee
Background: Limited in vivo studies in the scientific literature suggest that components of green tea and elderberry may be beneficial in treating influenza virus infections. They are thought to act by blocking virus adso...
Novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations [0.03%]
新型1,2,4-三氮唑和嘌呤类无环环丙烷核苷类似物：合成及抗病毒与细胞毒性活性评价
Krešimir Benci,Tomislav Suhina,Leo Mandić et al.
Krešimir Benci et al.
Background: Several published studies indicate that the acyclic guanine nucleoside analogues possessing bis(1,2-hydroxymethyl) substituted cyclopropane rings mimicking the sugar moiety are potent inhibitors of replication...
William H Prusoff dies at 90 - a renaissance man that revolutionized the treatment of herpesviruses and HIV [0.03%]
威廉·普鲁索夫去世享年90岁——革新时代疱疹和艾滋病治疗的“文艺复兴式人物”
Raymond F Schinazi
Raymond F Schinazi
Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus [0.03%]
蛋白酶抑制剂抑宁抑制甲型H1N1流感病毒的激活作用
Oleg P Zhirnov,Tatyana Y Matrosovich,Mikhail N Matrosovich et al.
Oleg P Zhirnov et al.
Background: The recent emergence of pandemic influenza virus H1N1v stresses the need for the development of new anti-influenza drugs. Methods: ...
Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design [0.03%]
基于片段筛选和结构设计识别HIV-1整合酶新抑制机制的结构基础
David I Rhodes,Thomas S Peat,Nick Vandegraaff et al.
David I Rhodes et al.
Background: HIV-1 integrase is a clinically validated therapeutic target for the treatment of HIV-1 infection, with one approved therapeutic currently on the market. This enzyme represents an attractive target for the dev...
Mohamed Rajik,Khatijah Yusoff
Mohamed Rajik
Influenza A virus is a particularly problematic virus because of its ability to cause high levels of morbidity on a global scale within a remarkably short period of time. It also has the potential to kill very large numbers of people as occ...
Small molecule pan-dengue and West Nile virus NS3 protease inhibitors [0.03%]
广谱登革病毒和西尼罗河病毒NS3蛋白酶抑制剂的小分子化合物
Lynne Cregar-Hernandez,Guan-Sheng Jiao,Alan T Johnson et al.
Lynne Cregar-Hernandez et al.
Background: Dengue fever, dengue haemorrhagic fever, and dengue shock syndrome are caused by infections with any of the four serotypes of the dengue virus (DENV), and are an increasing global health risk. The related West...
Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances [0.03%]
特选抗病毒物质治疗免疫抑制无毛小鼠的皮肤天花病毒感染
Donald F Smee,Kevin W Bailey,Min-Hui Wong et al.
Donald F Smee et al.
Background: Certain nucleoside, nucleotide and pyrophosphate analogues may be useful for treating severe complications arising as a result of virus dissemination following smallpox (live vaccinia virus) vaccinations, espe...
Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir [0.03%]
Maporal病毒作为致病的新世界汉坦病毒的替代品及其被favipiravir抑制作用的研究
Kristin K Buys,Kie-Hoon Jung,Donald F Smee et al.
Kristin K Buys et al.
Background: Pathogenic hantaviruses geographically distributed in the Old World cause haemorrhagic fever with renal syndrome (HFRS), whereas New World hantaviruses are the aetiological agents of hantavirus cardiopulmonary...