Inhibition of influenza virus replication by constrained peptides targeting nucleoprotein [0.03%]
针对核蛋白的约束肽抑制流感病毒复制
Hongbing Jiang,Yidong Xu,Li Li et al.
Hongbing Jiang et al.
Background: Because of high mutation rates, new drug-resistant viruses are rapidly evolving, thus making the necessary control of influenza virus infection difficult. ...
Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates [0.03%]
新型吲哚芳基磺胺衍生物与K103N和Y181I突变型HIV-1逆转录酶及其底物复合物的相互作用机制
Alberta Samuele,Sara Bisi,Alexandra Kataropoulou et al.
Alberta Samuele et al.
Background: Novel indolylarylsulfones (IASs), designed through rational structure-based molecular modelling and docking approaches, have been recently characterized as effective inhibitors of the wild-type and drug-resist...
Kundan B Ingale,Manish S Bhatia
Kundan B Ingale
Highly active antiretroviral therapy (HAART) significantly decreases plasma viral load, increases CD4+ T-cell counts in HIV-1-infected patients and has reduced progression to AIDS in developed countries. However, adverse side effects, and e...
Scientific report: highlights of 24th ICAR, 8-11 May 2011, Sofia, Bulgaria [0.03%]
第24届ICAR会议亮点报告(保加利亚索菲亚，2011年5月8-11日)
Anthony Vere Hodge
Anthony Vere Hodge
The 24th ICAR meeting was held in Sofia, Bulgaria, 8-11 May 2011. This report summarizes the presentations by the ICAR award winners, Earl Kern and Brian Gowen; the keynote address by Albert (ADME) Osterhaus; the Plenary lectures by Raina F...
Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds [0.03%]
评估筛选HIV-1整合酶非特异性DNA切刻刺激物系统的效果：在化合物库中的应用
Malgorzata Sudol,Jennifer L Fritz,Melissa Tran et al.
Malgorzata Sudol et al.
Background: In addition to activities needed to catalyse integration, retroviral integrases exhibit non-specific endonuclease activity that is enhanced by certain small compounds, suggesting that integrase could be stimul...
Synthesis of 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives with potential anti-HIV activity [0.03%]
一类具有抗HIV活性的1-苯甲基-3-(3,5-二甲基苯甲基)尿嘧啶衍生物的合成研究
Yohei Isono,Norikazu Sakakibara,Paula Ordonez et al.
Yohei Isono et al.
Background: Nine novel uracil analogues were synthesized and evaluated as inhibitors of HIV-1. Methods: Key structural modifications in...
Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effects on T-20 [0.03%]
包含形成深层疏水袋区域的N-HR衍生多肽表现出强大的抗HIV-1活性且不会对抗T-20产生拮抗效应
Kazuki Izumi,Kentaro Watanabe,Shinya Oishi et al.
Kazuki Izumi et al.
Background: Enfuvirtide (T-20), a C-terminal heptad repeat (C-HR)-derived peptide of HIV-1 glycoprotein, gp41, effectively suppresses HIV-1 replication through a putative mechanism that involves it acting as a decoy and b...
Michael J Sofia
Michael J Sofia
HCV infection is a significant worldwide health problem and is a major cause of hepatocellular carcinoma. The current standard of care, interferon and ribavirin, is only effective against a proportion of the patient population infected with...
The YMDD and rtA194T mutations result in decreased replication capacity in wild-type HBV as well as in HBV with precore and basal core promoter mutations [0.03%]
YMDD和rtA194T突变可降低野生型HBV以及含有前C和基础核心启动子突变的HBV的复制能力
Yuao Zhu,Maria Curtis,Katyna Borroto-Esoda
Yuao Zhu
Background: A recent study indicated that addition of the hepatitis B e antigen (HBeAg) precore (PC) or basal core promoter (BCP) mutations to wild-type HBV offset the reduced replication of the HBV polymerase rtA194T±rt...
Anti-influenza virus activity of tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone [0.03%]
染料木素的抗流感病毒活性研究
Kurumi Yazawa,Masahiko Kurokawa,Masatsugu Obuchi et al.
Kurumi Yazawa et al.
Background: We examined the anti-influenza virus activity of tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, against five viruses: A/Solomon islands/3/2006 (H1N1), A/Hiroshima/52/2005 (H3N2), A/California/07/2009 (H1N1p...