Inhibition of influenza A virus replication by antagonism of a PI3K-AKT-mTOR pathway member identified by gene-trap insertional mutagenesis [0.03%]
通过基因诱捕插入突变分析鉴定出抑制PI3K-AKT-mTOR通路成员并拮抗流感A病毒复制的作用机制
James L Murray,Natalie J McDonald,Jinsong Sheng et al.
James L Murray et al.
Background: Host genes serving potential roles in virus replication may be exploited as novel antiviral targets. Methods: Small interfe...
Phosphoramidate prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents [0.03%]
(-)-β-D-(2R,4R)-二氧戊环胸腺嘧啶(DOT)膦酸酰胺前药抗HIV活性研究
Peiyuan Wang,Suguna Rachakonda,Veronique Zennou et al.
Peiyuan Wang et al.
Background: Nucleoside reverse transcriptase inhibitors (NRTIs) are an effective class of agents that has played a vital role in the treatment of HIV infections. (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) is a thymidine ana...
Antiviral activity of recombinant mouse β-defensin 3 against influenza A virus in vitro and in vivo [0.03%]
重组小鼠β-防御素3在体内外对甲型流感病毒的抗病毒活性
Yan Jiang,De Yang,Wanyi Li et al.
Yan Jiang et al.
Background: Influenza causes significant morbidity and mortality. Mammalian β-defensins are small peptides of about 4.5-6 kDa in mass and are effectors of the innate immune response with potent antimicrobial activity. In...
Mark Hazebroek,Robert Dennert,Stephane Heymans
Mark Hazebroek
For over 50 years, viral infection has been recognized as an important trigger of acute myocarditis, inflammatory dilated cardiomyopathy (DCM) and congestive heart failure. Nevertheless, viral heart disease remains challenging to diagnose a...
Kristof Vrancken,Jan Paeshuyse,Sandra Liekens
Kristof Vrancken
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The limited treatment options and poor prognosis of HCC patients underscore the importance of developing new therapeutic strategies. Infection with HBV and HCV are ...
Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy [0.03%]
抗病毒疗法中的核苷膦酸前药的药物化学研究
Fabrizio Pertusati,Michaela Serpi,Christopher McGuigan
Fabrizio Pertusati
Considerable attention has been focused on the development of phosphonate-containing drugs for application in many therapeutic areas. However, phosphonate diacids are deprotonated at physiological pH and thus phosphonate-containing drugs ar...
Novel HIV-1 fusion inhibition peptides: designing the next generation of drugs [0.03%]
新一代艾滋病药物的設計：抗HIV-1融合肽的研究
Fusako Miyamoto,Eiichi N Kodama
Fusako Miyamoto
The development of over 20 antiretroviral drugs has led to efficient and successful suppression of HIV-1 replication. In addition to common viral targets, such as reverse transcriptase and protease, new targets have been recently exploited,...
The prophylaxis and treatment with antiviral agents of respiratory syncytial virus infections [0.03%]
抗病毒药物预防和治疗呼吸道合胞病毒感染
Pilar Najarro,Richard Angell,Kenneth Powell
Pilar Najarro
In this review, we consider recent advances in the discovery and development of antiviral agents for respiratory syncytial virus (RSV) infections. A background to the various manifestations of human RSV infection and current treatments is p...
Antiviral treatment of calves persistently infected with bovine viral diarrhoea virus [0.03%]
肉牛持续感染病毒的抗病毒治疗研究
Benjamin W Newcomer,M Shonda Marley,Patricia K Galik et al.
Benjamin W Newcomer et al.
Background: Animals persistently infected (PI) with bovine viral diarrhoea virus (BVDV) are a key source of viral propagation within and among herds. Currently, no specific therapy exists to treat PI animals. The purpose ...
Controlled Clinical Trial
Antiviral chemistry & chemotherapy. 2012 Jan 17;22(4):171-9. DOI:10.3851/IMP1903 2012
Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice [0.03%]
口服低剂量N-甲基卡巴胸苷对小鼠致死性单纯疱疹病毒2型感染的疗效研究
Debra C Quenelle,Deborah J Collins,Terri L Rice et al.
Debra C Quenelle et al.
Background: N-methanocarbathymidine (N-MCT) has previously been shown to be effective against lethal orthopoxvirus and herpes simplex virus type-1 infections in mice. In this investigation, the antiviral activity of N-MCT...