Andreas J Kesel,Hans-Christoph Weiss,Andreas Schönleber et al.
Andreas J Kesel et al.
Background: Amantadine constitutes an interesting, diamond crystal lattice-shaped, antivirally active amine with an inhibitory effect on influenza A viruses causing common 'flu' in humans. Unfortunately, amantadine forfei...
Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes [0.03%]
TLR7激动剂SMIP-7.7预防生殖器疱疹病毒感染小鼠模型中的HSV-2感染病症作用研究
David I Bernstein,Rhonda D Cardin,Fernando J Bravo et al.
David I Bernstein et al.
Background: Development of more effective therapies for genital herpes simplex virus type-2 (HSV-2) infections remains a priority. The toll-like receptors (TLR) are attractive targets for the immunomodulation of primary a...
Herpes simplex virus-1 encephalitis: a review of current disease management with three case reports [0.03%]
单纯疱疹病毒性脑炎：疾病管理的综述及三个病例报告
Michael J Skelly,Andrew A Burger,Oritsegbubemi Adekola
Michael J Skelly
Herpes simplex virus-1 (HSV-1) is the most common cause of lethal sporadic encephalitis. Despite improved therapy with intraveneous acyclovir, HSV-1 encephalitis is associated with persistent severe neurological deficits. We report three ca...
Exploration of the in vitro antiviral activity of a series of new pyrimidine analogues on the replication of HIV and HCV [0.03%]
一类新的嘧啶核苷类似物体外抗HIV和HCV复制活性的研究
Nadhir N A Jafar,Najim A Al-Masoudi,Sadiq J Baqir et al.
Nadhir N A Jafar et al.
Background: In continuation of our search for new anti-HIV and anti-HCV agents, the suggestion, synthesis and structure elucidation of a new series of 2,6-diamino-4-alkylthio- or (2-benzylhydrazinyl)-5-p-chlorophenylazopy...
Antiviral drug development--success and failure: a personal perspective with a Japanese connection [0.03%]
抗病毒药物研发的成功与失败——个人视角下的日本贡献
Erik De Clercq
Erik De Clercq
At the 25th International Conference on Antiviral Research, I received a special recognition for my contribution to the International Society of Antiviral Research over a period of 25 years (from 1987 until 2012). This review follows the th...
Professor De Clercq and 25 years of international collaboration on antiviral research [0.03%]
德克吕克教授与国际抗病毒研究合作25周年
Joseph M Colacino
Joseph M Colacino
Professor Erik De Clercq, recent recipient of the International Society for Antiviral Research (ISAR) 'Outstanding Contributions to the Society Award', recounts 25 years of antiviral research collaborating with his colleagues and friends in...
Scientific report: highlights of 25th ICAR, 16-19 April 2012, Sapporo, Japan [0.03%]
第25届ICAR会议亮点报告，2012年4月16-19日，日本札幌
Anthony Vere Hodge
Anthony Vere Hodge
Each year, the International Society for Antiviral Research (ISAR) organises a conference covering many differing aspects of antiviral research. The 25th International Conference on Antiviral Research (ICAR) was held in Japan. This special ...
Christopher Cianci,Samuel W Gerritz,Carol Deminie et al.
Christopher Cianci et al.
In the search for new anti-influenza agents, the viral polymerase has often been targeted due to the involvement of multiple conserved proteins and their distinct activities. Polymerase associates with each of the eight singled-stranded neg...
The application and mechanism of action of ribavirin in therapy of hepatitis C [0.03%]
利巴韦林治疗丙型肝炎的应用和作用机制
Emmanuel Thomas,Marc G Ghany,T Jake Liang
Emmanuel Thomas
Ribavirin has been used as an antiviral agent for several decades. Although it has activity against numerous viruses, its major use clinically has been in the treatment of respiratory syncytial virus in paediatric patients and chronic HCV i...
D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis [0.03%]
一种非核苷酸的流感病毒抑制剂D282可干扰从头合成嘧啶过程
Donald F Smee,Brett L Hurst,Craig W Day
Donald F Smee
Background: The discovery of novel influenza virus inhibitors remains an important priority in light of the emergence of drug-resistant viruses. Toward this end, a library of over 6,000 compounds was tested for antiviral ...