Inhibition of novel reassortant avian influenza H7N9 virus infection in vitro with three antiviral drugs, oseltamivir, peramivir and favipiravir [0.03%]
三种抗病毒药物奥司他韦、帕拉米韦和法维吡 ravir 体外抑制新型重组禽流感H7N9病毒感染
Rui-Yuan Cao,Jun-Hai Xiao,Bin Cao et al.
Rui-Yuan Cao et al.
Background: A novel reassortant avian-origin influenza A (H7N9) virus was isolated from respiratory specimens obtained from three patients and was identified as H7N9 in China. Antiviral agents are required to treat patien...
Pinar Iyidogan,Karen S Anderson
Pinar Iyidogan
Since its approval for clinical use in 2001, tenofovir (TFV) has become one of the most frequently prescribed nucleotide analogues used in combination with other antiretroviral agents against HIV-1 infection. Although reverse transcriptase ...
Samia A Elseginy,Alberto Massarotti,Galal Am Nawwar et al.
Samia A Elseginy et al.
West Nile virus (WNV) is a human pathogen which is rapidly expanding worldwide. It is a member of the Flavivirus genus and it is transmitted by mosquitos between its avian hosts and occasionally in mammalian hosts. In humans the infection i...
Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire [0.03%]
雷汀酮能抑制某些血液传播的人类病毒包括扎伊尔埃博拉病毒
Andreas J Kesel,Zhuhui Huang,Michael G Murray et al.
Andreas J Kesel et al.
Background: Human HBV and HIV integrate their retro-transcribed DNA proviruses into the human host genome. Existing antiretroviral drug regimens fail to directly target these intrachromosomal xenogenomes, leading to persi...
Riccardo Privolizzi,Roberto Solari,Sebastian L Johnston et al.
Riccardo Privolizzi et al.
Rhinoviruses are extremely common pathogens of the upper respiratory tract with adults experiencing on average 2-5 infections per year and children up to 12 infections. Although infections are not life threatening, except in cases of chroni...
Antivirally active ribavirin analogues--4,5-disubstituted 1,2,3-triazole nucleosides: biological evaluation against certain respiratory viruses and computational modelling [0.03%]
具有抗病毒活性的ribavirin类似物-4,5-取代的1,2,3-三氮唑核苷：对抗某些呼吸道病毒的生物评价及计算机建模研究
Anna Krajczyk,Katarzyna Kulinska,Tadeusz Kulinski et al.
Anna Krajczyk et al.
Background: Ribavirin is a broad-spectrum antiviral agent that derives some of its activity from inhibition of cellular inosine monophosphate dehydrogenase (IMPDH), resulting in lower guanosine triphosphate (GTP) levels. ...
Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus haemagglutinin blockers [0.03%]
一类新型硫代席洛侧链糖脂与金属纳米颗粒结合产物可有效阻断甲型流感病毒血凝素活性
Fei Feng,Yoshihiro Sakoda,Tatsuya Ohyanagi et al.
Fei Feng et al.
Background: The purpose of this study was to develop a new class of influenza A virus haemagglutinin (HA) blockers by tethering thiosialoside molecules to metal nanoparticles and producing glycoclusters that enhance the a...
Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus haemagglutinin blockers [0.03%]
一种新型硫代西格劳糖缀合金属纳米颗粒的抗病毒HA抑制剂活性研究
Fei Feng,Yoshihiro Sakoda,Tatsuya Ohyanagi et al.
Fei Feng et al.
Background: The purpose of this study was to develop a new class of influenza A virus haemagglutinin (HA) blockers by tethering thiosialoside molecules to metal nanoparticles and producing glycoclusters that enhance the a...
Erik De Clercq
Erik De Clercq
This review article focuses on the anti-herpesvirus agents effective against herpes simplex virus, varicella-zoster virus and cytomegalovirus, which have either been licensed for clinical use (idoxuridine, trifluridine, brivudin, acyclovir,...
Activity of a phenolic dibenzylsulfide against New World arenavirus infections [0.03%]
一种苯酚二苄硫醚对新世界 Arenavirus 感染的活性
Brian B Gowen,Kie-Hoon Jung,Eric J Sefing et al.
Brian B Gowen et al.
Background: Junín virus (JUNV) and several other clade B New World arenaviruses cause human disease ranging from mild febrile illness to severe viral haemorrhagic fever. These viruses pose a significant threat to nationa...