The continuing need for therapeutic agents for respiratory syncytial virus infection [0.03%]
呼吸道合胞病毒感染仍需研发治疗药物
Norbert J Roberts Jr
Norbert J Roberts Jr
Respiratory syncytial virus infections recur throughout life despite induction of immunity by the first natural infection. An effective vaccine has long been sought but no vaccine is currently licensed, although promising candidates are cur...
Erik De Clercq
Erik De Clercq
Brivudin, ((E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) can be considered the gold standard for the treatment of varicella-zoster virus (VZV) infections, such as herpes zoster (shingles). It is available for clinical use in most European cou...
Active site polymerase inhibitor nucleotides (ASPINs): Potential agents for chronic HBV cure regimens [0.03%]
活性位点聚合酶抑制核苷酸(ASPIN)：慢性乙型肝炎治愈的潜在药物成分
Robert G Gish,Tarik Asselah,Katherine Squires et al.
Robert G Gish et al.
Chronic hepatitis B virus (HBV) infection affects 240 to 300 million people worldwide. In the nucleus of infected hepatocytes, the HBV genome is converted to covalently closed circular DNA (cccDNA), which persists and serves as a transcript...
Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation) [0.03%]
庆祝雷加基金会五十年纪念——关于雷加医学研究所的回顾与展望
Erik De Clercq
Erik De Clercq
The idea to start the Rega Foundation was conceived in 1971 at an informal meeting organized by Prof. Piet De Somer (where Prof. Alfons Billiau, Prof. André Vlerick and I were also present), before the Foundation was formally created in 19...
Andrea Brancale,Kara Carter,Leen Delang et al.
Andrea Brancale et al.
As a result of the multiple gathering and travels restrictions during the SARS-CoV-2 pandemic, the annual meeting of the International Society for Antiviral Research (ISAR), the International Conference on Antiviral Research (ICAR), could n...
Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health [0.03%]
oleandrin和PBI-05204对商业肉牛健康的重要牛病毒的疗效研究
Robert A Newman,Christopher C L Chase,Jose R Matos et al.
Robert A Newman et al.
Background: Bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV). and bovine coronavirus (BCV) threaten the productivity of cattle worldwide. Development of therapeutics that can control the sprea...
Hranush Avagyan,Anaida Mirzoyan,Ferdinand Mirzoyan et al.
Hranush Avagyan et al.
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na2WO4 × 2H2O and Aluminum sulfate octadecahydrate-Al2 (SO4) 3 × 18H2O that we have conditionally named 'Vomifal' has a broad antiviral act...
Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model [0.03%]
3,19-异丙叉andrographolide抗HSV-1的活性研究
Jureeporn Chuerduangphui,Thawaree Nukpook,Chamsai Pientong et al.
Jureeporn Chuerduangphui et al.
Background: In our previous study, the semi-synthetic analog of andrographolide, 3,19-isopropylideneandrographolide (IPAD), acts more effectively against herpes simplex virus (HSV) infection in cell culture than does acyc...
Anti-influenza virus activity of the elenolic acid rich olive leaf (Olea europaea L.) extract Isenolic® [0.03%]
橄榄叶(Isenolic®)中富含依列蘊酸的抗流感病毒活性研究
Aurora Salamanca,Paula Almodóvar,Irene Jarama et al.
Aurora Salamanca et al.
Seasonal flu is caused by influenza infection, a virus that spreads easily in human population with periodical epidemic outbreaks. The high mutational rate of influenza viruses leads to the emergence of strains resistant to the current trea...
Clinical severe acute respiratory syndrome coronavirus 2 isolation and antiviral testing [0.03%]
临床严重急性呼吸系统综合症冠状病毒2的分离与抗病毒测试
Gregory Mathez,Valeria Cagno
Gregory Mathez
Severe acute respiratory syndrome coronavirus 2 is an RNA virus currently causing a pandemic. Due to errors during replication, mutations can occur and result in cell adaptation by the virus or in the rise of new variants. This can change t...