Giampaolo Collecchia
Giampaolo Collecchia
The temporal relationship between atrial fibrillation (AF) and stroke has always been considered one-way: the presence of arrhythmia favors the occurrence of stroke. Recent studies have questioned this association and raised the possibility...
[2020: Evidence-Based Medicine odyssey. The fall and rise of evidence-based medicine in the year of coronavirus] [0.03%]
[Evidence-Based Medicine的十年回顾：在新型冠状病毒之年里探究Evidence-Based Medicine的兴衰历程]
Maurizio Koch
Maurizio Koch
It was a very dark year for EBM. One of the side effects of the Covid-19 pandemic is a severe compression of the evidences. Here are some worrying events. May 2020: the saga of hydroxychloroquine. October 2020: the nitazoxanide case. Novemb...
Sandro Spinsanti
Sandro Spinsanti
Informed consent for CoViD-19 vaccines can be considered a step that can help us focus on an increasingly burdensome problem for contemporary medicine: the difficult relationship of trust between citizens and academic medicine. Filling out ...
[Target therapies in translocated ALK lung cancer: treatment management in oncology center of Lazio] [0.03%]
[洛伦佐拉齐奥肿瘤中心ALK易位肺癌靶向治疗的管理]
Serena Ricciardi,Fabiana Cecere,Mario Rosario D&#x;Andrea et al.
Serena Ricciardi et al.
Lung cancer is a disease extremely heterogeneous in the molecular aspect and knowing the mutational profile of patients is essential in order to initiate the most appropriate treatment. In 2018, alectinib was approved in Italy for the first...
[Ceritinib in the treatment of an adult patient with advanced neuroblastoma positive to the somatic activating mutation of ALK F1174L] [0.03%]
卡博替尼治疗ALK-F1174L突变阳性神经母细胞瘤一例报告
Hector Josè Soto Parra,Laura Noto,Marco Maria Aiello
Hector Josè Soto Parra
The ALK gene (anaplastic lymphoma kinase) encodes a highly conserved tyrosine kinase receptor whose physiological function has not yet been fully established; in particular the fusion of ALK (mainly EML4-ALK) is the gene alteration that mos...
Mauro Minelli,Federica Buzzacchino,Silverio Tomao et al.
Mauro Minelli et al.
Among solid tumors, non-small cell lung cancer (NSCLC) represents the paradigm of the application of precision medicine to clinical practice. Understanding many biomolecular mechanisms in the determinism of NSCLC has ensured the development...
Ernesto Rossi
Ernesto Rossi
The treatment of cutaneous melanoma harboring BRAF mutation has been greatly enriched. BRAF/MEK inhibitors can improve the outcome of patients with this disease. On the other hand, immunotherapy can also be effective. A focus on the role of...
[he role of immunotherapy for the adjuvant treatment of BRAF-mutant melanoma] [0.03%]
免疫疗法用于BRAF突变型黑色素瘤辅助治疗的作用
Francesco Spagnolo
Francesco Spagnolo
The introduction of anti-PD-1 drugs as an adjuvant treatment for high risk melanoma has radically changed the everyday clinical practice, with an impact on the reduction of the risk of relapse close to 50%, as observed in phase 3 clinical t...
Fabrizio Elia,Fabrizio Vallelonga
Fabrizio Elia
The second pandemic wave flooded Italy and Europe. There are many reasons to be concerned but, as health care workers, we want to emphasize something particular. We reacted with enormous sacrifices during the first pandemic wave, despite th...