Sabina Chiaretti,Monica Messina,Simona Tavolaro et al.
Sabina Chiaretti et al.
Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to i...
Robin Foà
Robin Foà
Acute lymphoblastic leukemia (ALL) is the most frequent neoplasm in children, while being relatively rare in adults. The outcome of children with ALL is far superior than that observed in adults, whose survival rates generally do not exceed...
Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide [0.03%]
低剂量全身照射结合单倍型相合造血干细胞移植后高剂量环磷酰胺预处理疗法
Ashley Munchel,Chimen Kesserwan,Heather J Symons et al.
Ashley Munchel et al.
Allogeneic stem cell transplantation (SCT) from an HLA-haploidentical relative provides a potentially curative treatment option for hematologic malignancies patients who lack a suitably HLA-matched donor. The greatest challenge to performin...
Franco Aversa
Franco Aversa
Interest in mismatched transplantation arises from the fact that a suitable one-haplotype mismatched donor is immediately available for virtually all patients, particularly for those who urgently need an allogenic transplant. Work on one ha...
T cell-depleted hla-haploidentical stem cell transplantation in thalassemia young patients [0.03%]
单倍体移植治疗输血依赖型地中海贫血患者
Pietro Sodani,Antonella Isgrò,Javid Gaziev et al.
Pietro Sodani et al.
HLA-mismatched hematopoietic stem cell tranplantation for pediatric solid tumors [0.03%]
儿童实体瘤患者的造血干细胞移植术中的HLA不全合的临床意义
Andrea Pession,Riccardo Masetti,Corinne Di Leo et al.
Andrea Pession et al.
Even if the overall survival of children with cancer is significantly improved over these decades, the cure rate of high-risk pediatric solid tumors such as neuroblastoma, Ewing's sarcoma family tumors or rhabdomiosarcoma remain challenging...
Paul Veys
Paul Veys
Studies so far indicate that reduced intensity transplantation (RIT) may have an important role in treating patients with primary immunodeficiency disease (PID). Unlike more standard approaches, such regimens can be used without severe toxi...
The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome [0.03%]
RPS14单剂量不足和p53活化在5q综合征分子发病机制中的作用
Jacqueline Boultwood
Jacqueline Boultwood
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a distinct subtype of myelodysplasia. The demonstration of haploinsufficiency of the ribosomal gene RPS14 (mapping to the commonly deleted reg...
Josep-Maria Ribera
Josep-Maria Ribera
Acute lymphoblastic leukemia (ALL) is the most frequent neoplastic disease in children, being a rare disease in adults. Many of the advances in pediatric ALL have been through modifications in the doses and schedules of available agents as ...
Temporary brittle bone disease: relationship between clinical findings and judicial outcome [0.03%]
暂时性骨质疏松症的临床表现与司法结论的关系
Colin R Paterson,Elizabeth A Monk
Colin R Paterson
There is a wide differential diagnosis for the child with unexplained fractures including non-accidental injury, osteogenesis imperfecta and vitamin D deficiency rickets. Over the last 20 years we and others have described a self-limiting s...