Comparison of the methods of fibrinolysis by tube thoracostomy and thoracoscopic decortication in children with stage II and III empyema: a prospective randomized study [0.03%]
一期和二期脓胸患儿不同祛除纤维板包裹的方法比较：前瞻性随机研究
Ufuk Cobanoglu,Fuat Sayir,Salim Bilici et al.
Ufuk Cobanoglu et al.
Today, in spite of the developments in imaging methods and antibiotherapy, childhood pleural empyema is a prominent cause of morbidity and mortality. In recent years, it has been shown that there has been an increase in the frequency of ple...
B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia [0.03%]
利妥昔单抗反复治疗后依赖糖皮质激素的自身免疫性溶血性贫血患儿B淋巴细胞重建
Annelieke A A van der Linde,Ellen J H Schatorjé,Annemieke M van der Weij et al.
Annelieke A A van der Linde et al.
We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic...
Kazunari Kaneko,Takahisa Kimata,Shoji Tsuji et al.
Kazunari Kaneko et al.
Obese patients are known to have greater risks to develop hypertension, coronary vascular disease, and insulin resistance, and more attention has been recently paid to the impact of obesity on kidney. This study was conducted to investigate...
Born at 27 weeks of gestation with classical PKU: challenges of dietetic management in a very preterm infant [0.03%]
早产27周患典型苯丙酮尿症(PKU)的婴儿的饮食管理挑战
Diana Ballhausen,Delphine Egli,Myriam Bickle-Graz et al.
Diana Ballhausen et al.
Few cases of premature infants with classical phenylketonuria (PKU) have been reported. Treatment of these patients is challenging due to the lack of a phenylalanine (Phe)-free amino acid (AA) solution for parenteral nutrition. A boy born a...
Case Reports
Pediatric reports. 2011 Sep 30;3(4):e26. DOI:10.4081/pr.2011.e26 2011
Severe congenital neutropenia, a genetically heterogeneous disease group with an increased risk of AML/MDS [0.03%]
严重先天性中性粒细胞减少症是一种遗传异质性疾病，患急性髓系白血病/骨髓增生异常综合征的风险增加
Peter Vandenberghe,Karolien Beel
Peter Vandenberghe
OVER THE PAST DECADE, ENORMOUS PROGRESS HAS BEEN MADE IN THE UNDERSTANDING OF SEVERE CONGENITAL NEUTROPENIA (SCN), BY IDENTIFICATION OF SEVERAL CAUSAL GENE MUTATIONS: in ELANE, GFI1, HAX1, WAS and G3PC3. SCN is a preleukemic condition, inde...
Johanna Svahn,Carlo Dufour
Johanna Svahn
Fanconi Anemia (FA) is a rare autosomic recessive and X-linked disease with chromosomal instability after exposure to crosslinking agents as the hallmark. Clinical features of FA are somatic malformations, progressive bone marrow failure an...
Antonio M Risitano,Fabiana Perna
Antonio M Risitano
Acquired aplastic anemia (AA) is the typical bone marrow failure syndrome characterized by an empty bone marrow; an immune-mediated pathophysiology has been demonstrated by experimental works as well as by clinical observations. Immunusuppr...
Paolo Sportoletti
Paolo Sportoletti
NPM1 is the most frequently mutated gene in AML and the role of the NPM1 mutant in acute myeloid leukemia along with its leukemogenic potential are still under investigation.NPM1 genetic alterations can contribute to leukemogenesis through ...
Stefano A Pileri,Claudio Agostinelli,Francesco Bacci et al.
Stefano A Pileri et al.
The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main h...
New genetics and diagnosis of childhood B-cell precursor acute lymphoblastic leukemia [0.03%]
儿童前体B细胞急性淋巴细胞白血病的新遗传学和诊断方法
Christine Harrison
Christine Harrison
Over the last 50 years, while significant advances have been made in the successful treatment of childhood leukaemia, similar progress has been made in understanding the genetics of the disease. In childhood B-cell precursor acute lymphobla...