PHF10 is a Novel Substrate of Keap1 to Protect Non-Small-Cell Lung Cancer (NSCLC) Cells Against Oxidative Stress and Confer Ferroptosis Resistance [0.03%]
KEAP1的新底物PHF10通过保护非小细胞肺癌(NSCLC)细胞抵抗氧化应激并赋予其铁死亡耐受性发挥作用
Xuan Lu,Ningning Kang,Yajun Chen et al.
Xuan Lu et al.
Purpose: Keap1 mutations mainly caused NRF2-dependent anti-oxidative stress responses, yet whether there are other downstream substrates and pathways remains unknown. This study aimed to uncover the role of Keap1 mutation...
Longitudinal Circulating Tumor DNA Profiling as a Biomarker for Response and Resistance in Platinum-Refractory Head and Neck Squamous Cell Carcinoma [0.03%]
基于铂类耐药的头颈部鳞状细胞癌纵向循环肿瘤DNA谱分析作为应答和抗性的生物标志物研究
Wonyoung Choi,Jong-Ho Lee,Junsun Ryu et al.
Wonyoung Choi et al.
Purpose: Immune checkpoint inhibitors (ICIs) are the standard treatment for platinum-refractory head and neck squamous cell carcinoma (HNSCC). This study aimed to characterize genomic alterations, monitor dynamic changes ...
Phase 1 Study of IMC-002, a Next-Generation Anti-CD47 Antibody, in Advanced Solid Tumors [0.03%]
IMC-002治疗晚期实体瘤的Ⅰ期临床试验：一种下一代抗CD47单克隆抗体
Jin Seok Ahn,Jung Yong Hong,Joon Oh Park et al.
Jin Seok Ahn et al.
Purpose: IMC-002 is a fully human cluster of differentiation 47-targeted immunoglobulin G4 monoclonal antibody, designed to minimize off-target effects. This study (NCT05276310) assessed its safety/tolerability and prelim...
Impact of Cell-of-Origin and MYC/BCL2 Status on the Risk of Central Nervous System Relapse in Primary Breast Diffuse Large B-Cell Lymphoma [0.03%]
原发性乳腺弥漫性大B细胞淋巴瘤中原始细胞起源和MYC/BCL2状态对中枢神经系统复发风险的影响
Chang-Hoon Lee,Ga-Young Song,Ho-Young Yhim et al.
Chang-Hoon Lee et al.
Purpose: Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare entity with a distinct relapse pattern involving the central nervous system (CNS). However, data regarding predictors of CNS relapse in this populati...
Real World Efficacy and Safety of First Line Chemo Immunotherapy in Extensive Stage Small Cell Lung Cancer and its association with molecular subtype [0.03%]
一线化疗联合免疫治疗广泛期小细胞肺癌的疗效和安全性以及其与分子亚型的关系分析
Miran Han,Sehhoon Park,Se-Hoon Lee et al.
Miran Han et al.
Purpose: Small cell lung cancer (SCLC) is an aggressive malignancy with poor outcomes. IMpower133 and CASPIAN established platinum-etoposide plus anti-PD-L1 antibody as standard first-line therapy for extensive-stage SCLC...
The Impact of Post Mastectomy Radiotherapy on T1-2N0-1 Male Breast Cancer and establishment of an artificial neural network predicting model: Population-Based Study [0.03%]
保乳术后男性乳腺癌T1-2N0-1患者术后放疗影响的队列研究及人工智能预测模型构建
Kaiyan Huang,Yushuai Yu,Xiaofen Li et al.
Kaiyan Huang et al.
Purpose: The objective of this study was to analyze the impact of post-mastectomy radiotherapy (PMRT) in male breast cancer (MBC) patients and develop an artificial neural network (ANN) model to identify a potential PMRT ...
Predictive Role of Baseline Peripheral Lung SUVmax on PET/CT for Immune-Related Pneumonitis and Adverse Events in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors [0.03%]
基线外周型肺癌SUVmax对免疫检查点抑制剂治疗的肺损伤及不良事件的预测作用
Kun Ho Kim,Seong Min Kim,Jeong Eun Lee et al.
Kun Ho Kim et al.
Purpose: Immune checkpoint inhibitors (ICIs) offer durable responses in lung cancer patients lacking actionable mutations or with resistance to prior therapies. However, predicting their efficacy and associated immune-rel...
Chemoradiotherapy Increases the Incidence Rate of Cachexia in Head and Neck Cancer: A Cohort Study [0.03%]
化疗增力口头颈部肿瘤恶病质患病率的队列研究
Nan-Chin Lin,Kuo-Ting Sun,Yu-Hsin Tseng et al.
Nan-Chin Lin et al.
Purpose: In Taiwan, head and neck cancer (HNC) ranks among the five most prevalent cancers in men. HNC tumours can impair the patient's ability to ingest food following treatment, which may lead to cachexia. Currently, in...
Clinical Outcomes and Histologic Subtype-Specific Patterns in Oligometastatic Soft Tissue Sarcoma of the Extremities and Trunk Wall: Implications for Curative Local Ablative Therapy [0.03%]
四肢和躯干软组织肉瘤寡转移的临床转归及组织学亚型特异性模式：根治性局部消融治疗的启示
Eunkyu Yang,Han-Soo Kim,Jay Hoon Park et al.
Eunkyu Yang et al.
Purpose: Oligometastatic soft tissue sarcoma (STS) may offer the possibility of cure compared with polymetastatic disease, with progression patterns and treatment responses varying across histologic subtypes. This study i...
Trajectory of Lymph Node Metastasis Reflects the Molecular Features of Esophageal Squamous Cell Carcinoma [0.03%]
淋巴结转移路径反映了食管鳞癌的分子特征
Jiho Park,Seong Yong Park,Ha Eun Kim et al.
Jiho Park et al.
Purpose: Esophageal squamous cell carcinoma (ESCC) is frequently accompanied by lymph node metastasis (LNM) to the neck, chest, and abdomen. Despite its significance as a key prognostic factor, the genomic trajectory of L...