Pemetrexed Maintenance versus Observation in Patients with Advanced Urothelial Carcinoma Who Completed First-line Platinum-based Chemotherapy without Disease Progression (PREMIER, KCSG GU16-05) [0.03%]
一线含铂化疗未进展的晚期尿路上皮癌患者维持治疗与观察：培美曲塞与空白对照的多中心、随机、双盲III期临床试验（PREMIER，KCSG GU16-05）
Inkeun Park,Shinkyo Yoon,Ilhwan Kim et al.
Inkeun Park et al.
Purpose: Platinum-based chemotherapy is the standard treatment for advanced urothelial carcinoma (aUC). Switch maintenance therapy after first-line (1L) treatment may delay disease progression. This study evaluated pemetr...
Sex-specific Molecular Markers NRF2 and PD-L1 in Colon Carcinogenesis: Implications for Right-sided Colon Cancer [0.03%]
结肠癌变中性别特异性分子标志物NRF2和PD-L1：右侧结肠癌的预后意义
Chin-Hee Song,Yonghoon Choi,Nayoung Kim et al.
Chin-Hee Song et al.
Purpose: This study examined the roles of nuclear factor erythroid 2-related factor 2 (NRF2) and programmed death ligand 1 (PD-L1) in colon carcinogenesis, underscoring on sex and differences in tumor location. ...
Relationships between the Microbiome and Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer [0.03%]
局部晚期直肠癌新辅助放化疗疗效与微生物组的关系研究
Hye In Lee,Bum-Sup Jang,Ji Hyun Chang et al.
Hye In Lee et al.
Purpose: This study aimed to investigate the dynamic changes in the microbiome of patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (nCRT), focusing on the relationship between t...
Phase II Trial of Neoadjuvant Docetaxel/Cisplatin/5-Fluorouracil Combined with Pegteograstim for Unresectable, Locally Advanced Sinonasal Squamous Cell Carcinoma: KCSG HN18-07 [0.03%]
不可切除的局部晚期鼻腔鼻窦癌术前多西他赛/顺铂/5-氟尿嘧啶联合培非格司亭新辅助化疗方案Ⅱ期临床研究：KCSG HN18-07
Bhumsuk Keam,Ho Jung An,Seong Hoon Shin et al.
Bhumsuk Keam et al.
Purpose: The role of neoadjuvant chemotherapy in locally advanced sinonasal squamous cell carcinoma (SNSCC) has not been established prospectively. We conducted a phase II trial of neoadjuvant chemotherapy (NAC) with doce...
A Machine Learning Risk Prediction Model for Gastric Cancer with SHapley Additive exPlanations [0.03%]
基于SHapley Additive exPlanations胃癌机器学习风险预测模型
Bomi Park,Chung Ho Kim,Jae Kwan Jun et al.
Bomi Park et al.
Purpose: Gastric cancer (GC) prediction models hold potential for enhancing early detection by enabling the identification of high-risk individuals, facilitating personalized risk-based screening, and optimizing the alloc...
Role and Effectiveness of Hypofractionated Proton Beam Therapy and Combinations with Systemic Chemotherapy in Inoperable Extrahepatic Cholangiocarcinoma [0.03%]
不可切除的额外肝胆管癌中低分割质子束治疗及其与系统化疗联合应用的作用和有效性
Sung Uk Lee,Tae Hyun Kim,Sang Myung Woo et al.
Sung Uk Lee et al.
Purpose: This study aims to assess the clinical outcomes of hypofractionated proton beam therapy (PBT) for extrahepatic cholangiocarcinoma (EHCC) and to investigate the optimal sequencing for combining PBT with chemothera...
ALK Inhibition in a Patient with Inflammatory Myofibroblastic Tumor Harboring CARS1-ALK Fusion [0.03%]
携带CARS1-ALK融合基因炎性肌纤维母细胞瘤患者的ALK抑制治疗
Songji Choi,Miso Kim,Sheehyun Kim et al.
Songji Choi et al.
Inflammatory myofibroblastic tumor (IMT) is a rare entity, primarily affecting young individuals, often involving the abdomen, pelvis, or lung. Approximately 50% of IMTs harbor ALK gene rearrangements, making ALK inhibitors a viable treatme...
Case Reports
Cancer research and treatment. 2024 Dec 18. DOI:10.4143/crt.2024.1184 2024
The HDAC Inhibitor Entinostat Mediates HER2 Downregulation in Gastric Cancer, Providing the Basis for Its Particular Efficacy in HER2 Amplified Tumors and in Combination Therapies [0.03%]
HDAC抑制剂Entinostat介导胃癌中HER2下调，为其在HER2扩增肿瘤和联合治疗中的特异性疗效提供依据
Tamara Zenz,Robert Jenke,René Thieme et al.
Tamara Zenz et al.
Purpose: HER2 inhibition represents a therapeutic approach with proven clinical efficacy in gastric cancer. However, resistance against HER2-directed therapeutics highlights the need for alternative approaches or drug com...
Identifying Anti-Cancer Effects and Exploring the Mechanism of an MPS1/TTK Inhibitor in Gastric Cancer [0.03%]
识别MPS1/TTK抑制剂在胃癌中的抗肿瘤效果及作用机制研究
Eunseo Kim,Woo Sun Kwon,Tae Soo Kim et al.
Eunseo Kim et al.
Purpose: To identify the anti-cancer effect and investigate the underlying mechanism of MPS1/TTK (Monopolar spindle 1; also known as threonine tyrosine kinase) inhibitor in gastric cancer (GC) cell lines. ...
Associations of Financial Toxicity with Employment Concerns and Cancer-Related Distress: A Cross-Sectional Survey among Korean Working-Age Cancer Survivors [0.03%]
财务毒性与就业担忧和癌症相关困扰之间的关联——一项针对韩国癌症幸存者横断面调查研究
Hyun-Ju Seo,Dal-Lae Jin,Young Ae Kim et al.
Hyun-Ju Seo et al.
Purpose: Although South Korea's health insurance has a co-payment-decreasing policy for cancer survivors, information on the extent of financial toxicity and its related factors is limited. We assessed the level of financ...